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1. (WO2018127918) A SIRP ALPHA-CD70 FUSION PROTEIN AND METHODS OF USE THEREOF
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Pub. No.: WO/2018/127918 International Application No.: PCT/IL2018/050016
Publication Date: 12.07.2018 International Filing Date: 04.01.2018
IPC:
A61K 38/17 (2006.01) ,C07K 14/705 (2006.01) ,C07K 19/00 (2006.01) ,A61P 35/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
705
Receptors; Cell surface antigens; Cell surface determinants
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
19
Hybrid peptides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
KAHR MEDICAL LTD. [IL/IL]; 1 Kiryat Hadassa JDP Building, 4th Floor 9112001 Jerusalem, IL
Inventors:
SHANI, Noam; IL
GOZLAN, Yosi; IL
DRANITZKI ELHALEL, Michal; IL
BREMER, Edwin; NL
KAMINSKY, Ido; IL
Agent:
EHRLICH, Gal; IL
WATERMAN, Hadassa; IL
MELNICK, Geoffrey, L.; IL
Priority Data:
62/442,46005.01.2017US
Title (EN) A SIRP ALPHA-CD70 FUSION PROTEIN AND METHODS OF USE THEREOF
(FR) PROTÉINE DE FUSION SIRP ALPHA-CD70 ET SES PROCÉDÉS D'UTILISATION
Abstract:
(EN) SIRPalpha-CD70 fusion proteins are provided. Accordingly, there is provided a SIRPalpha- CD70 fusion protein comprising a single amino acid linker between the SIRPalpha and the CD70. Also there is provided a SIRPalpha-CD70 fusion protein in a form of at least a homo- trimer. Also provided are polynucleotides and nucleic acid constructs encoding the SIRPalpha- CD70 fusion protein, host-cells expressing the SIRPalpha-CD70 fusion protein and methods of use thereof.
(FR) L'invention concerne des protéines de fusion SIRPalpha-CD70. En conséquence, l'invention concerne une protéine de fusion SIRPalpha-CD70 comprenant un seul lieur d'acide aminé entre le SIRPalpha et le CD70. L'invention concerne également une protéine de fusion SIRPalpha-CD70 sous la forme d'au moins un homo-trimère. L'invention concerne en outre des polynucléotides et des constructions d'acides nucléiques codant pour la protéine de fusion SIRPalpha- CD70, des cellules hôtes exprimant la protéine de fusion SIRPalpha-CD70 et leurs procédés d'utilisation.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)