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1. (WO2018127916) A PD1-CD70 FUSION PROTEIN AND METHODS OF USE THEREOF

Pub. No.:    WO/2018/127916    International Application No.:    PCT/IL2018/050014
Publication Date: Fri Jul 13 01:59:59 CEST 2018 International Filing Date: Fri Jan 05 00:59:59 CET 2018
IPC: C07K 14/705
A61K 38/17
A61P 35/00
C07K 19/00
Applicants: KAHR MEDICAL LTD.
Inventors: SHANI, Noam
GOZLAN, Yosi
DRANITZKI ELHALEL, Michal
BREMER, Edwin
KAMINSKY, Ido
Title: A PD1-CD70 FUSION PROTEIN AND METHODS OF USE THEREOF
Abstract:
PD1-CD70 fusion proteins are provided. Accordingly, there is provided a PD1-CD70 fusion protein comprising a single amino acid linker between the PD1 and the CD70. Also there is provided a PD1-CD70 fusion protein, wherein the PD1 amino acid is 123-166 amino acids in length and/or wherein the PD1 amino acid sequence comprises SEQ ID NO: 2 and/or wherein the fusion protein is in a form of at least a homo-trimer. Also provided are polynucleotides and nucleic acid constructs encoding the PD1-CD70 fusion protein, host-cells expressing the PD1-CD70 fusion protein and methods of use thereof.