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1. (WO2018127850) THREE-DIMENSIONAL TUMOR MODELS, METHODS OF MANUFACTURING SAME AND USES THEREOF

Pub. No.:    WO/2018/127850    International Application No.:    PCT/IB2018/050109
Publication Date: Fri Jul 13 01:59:59 CEST 2018 International Filing Date: Tue Jan 09 00:59:59 CET 2018
IPC: A61B 34/10
G09B 23/30
B33Y 80/00
Applicants: RAMOT AT TEL-AVIV UNIVERSITY LTD.
Inventors: SATCHI-FAINARO, Ronit
NEUFELD, Lena
TIRAM, Galia
BEN-SHUSHAN, Dikla
Title: THREE-DIMENSIONAL TUMOR MODELS, METHODS OF MANUFACTURING SAME AND USES THEREOF
Abstract:
A three dimensional (3D) model of a tumor made of a synthetic material and a plurality of cell types, including malignant cells and non-malignant cells of the tumor, having a full HLA match, such that the synthetic material and the plurality of cell types are arranged in high matchability to a 3D image of the tumor, is provided. Methods of forming the 3D tumor model by bioprinting are also provided, as well as systems in which the 3D tumor model can be perfused and fluidly connected to a medium containing immune cells and/or other cells and factors present in the tumor's microenvironment. Methods utilizing the 3D tumor model or the system in, for example, personalized therapy, are also provided.