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1. (WO2018127806) PROCESS FOR PREPARATION OF ISOPROTERENOL HYDROCHLORIDE
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Pub. No.: WO/2018/127806 International Application No.: PCT/IB2018/050031
Publication Date: 12.07.2018 International Filing Date: 03.01.2018
IPC:
C07C 213/00 (2006.01) ,C07C 213/10 (2006.01) ,C07C 215/60 (2006.01) ,C07C 215/66 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
213
Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
213
Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
10
Separation; Purification; Stabilisation; Use of additives
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
215
Compounds containing amino and hydroxy groups bound to the same carbon skeleton
46
having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
56
with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by hydroxy groups
58
with hydroxy groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
60
the chain having two carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
215
Compounds containing amino and hydroxy groups bound to the same carbon skeleton
46
having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
66
with quaternised amino groups bound to the carbon skeleton
Applicants:
EMCURE PHARMACEUTICALS LIMITED [IN/IN]; Emcure House, T-184, M.I.D.C., Bhosari Pune 411026, IN
Inventors:
GURJAR, Mukund Keshav; IN
JOSHI, Shashikant Gangaram; IN
JAGTAP, Jagannath Tulsiram; IN
BADHE, Sachin Arvind; IN
Priority Data:
20172100070807.01.2017IN
Title (EN) PROCESS FOR PREPARATION OF ISOPROTERENOL HYDROCHLORIDE
(FR) PROCÉDÉ DE PRÉPARATION DE CHLORHYDRATE D'ISOPROTÉRÉNOL
Abstract:
(EN) The present invention provides a process for preparation of isoproterenol hydrochloride (1a) comprising catalytic hydrogenation of 3',4'-dihydroxy-2-(isopropylamino)-acetophenone hydrochloride (5a) in presence of an ion exchange resin, to provide isoproterenol hydrochloride (1a).
(FR) La présente invention concerne un procédé de préparation de chlorhydrate d'isoproterénol (1a) comprenant l'hydrogénation catalytique de chlorhydrate de 3',4'-dihydroxy-2-(isopropylamino)-acétophénone (5a) en présence d'une résine échangeuse d'ions, pour fournir du chlorhydrate d'isoprotérénol (1a).
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)