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1. (WO2018127594) ORAL DOSAGE FORM FOR ENHANCED SOLUBILIZATION OF A POORLY SOLUBLE ACTIVE AGENT AND METHOD OF PREPARATION

Pub. No.:    WO/2018/127594    International Application No.:    PCT/EP2018/050383
Publication Date: Fri Jul 13 01:59:59 CEST 2018 International Filing Date: Tue Jan 09 00:59:59 CET 2018
IPC: A61K 9/00
A61K 9/16
A61K 9/20
A61K 31/00
Applicants: OYSTERSHELL NV
Inventors: ROSSEL, Bart
Title: ORAL DOSAGE FORM FOR ENHANCED SOLUBILIZATION OF A POORLY SOLUBLE ACTIVE AGENT AND METHOD OF PREPARATION
Abstract:
The present invention provides and oral dosage form comprising a granular phase and a non-granular phase, whereby said granular phase is comprised of a therapeutically effective amount of pharmaceutically active agent, a gas forming agent and a hydrophilic polymer. Such dosages are found to provide fast dissolution rates for ingredients having low solubility in water. In addition, the present invention provides a method of preparation thereof.