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1. (WO2018127585) MONOSPECIFIC REGULATORY T CELL POPULATION WITH CYTOTOXICITY FOR B CELLS

Pub. No.:    WO/2018/127585    International Application No.:    PCT/EP2018/050347
Publication Date: Fri Jul 13 01:59:59 CEST 2018 International Filing Date: Tue Jan 09 00:59:59 CET 2018
IPC: C12N 5/0783
A61K 39/00
Applicants: TXCELL
Inventors: ZHOU, Li
MEYER, François
ABEL, Tobias
GERTNER-DARDENNE, Julie
Title: MONOSPECIFIC REGULATORY T CELL POPULATION WITH CYTOTOXICITY FOR B CELLS
Abstract:
The present invention relates to a monospecific population of Treg cells, wherein the Treg cells comprise a chimeric receptor, wherein said chimeric receptor recognizes an autoantibody on a B cell, and wherein said Treg cells are cytotoxic for B cells. The present invention also relates to methods for obtaining said monospecific Treg cell population and to the use of said monospecific Treg cell population, in particular for treating an autoantibody-mediated autoimmune disease.