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1. (WO2018127584) MONOSPECIFIC REGULATORY T CELL POPULATION WITH CYTOTOXICITY FOR B CELLS
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Pub. No.: WO/2018/127584 International Application No.: PCT/EP2018/050342
Publication Date: 12.07.2018 International Filing Date: 08.01.2018
IPC:
C12N 5/0783 (2010.01) ,A61K 35/17 (2015.01) ,C07K 16/30 (2006.01)
[IPC code unknown for C12N 5/0783][IPC code unknown for A61K 35/17][IPC code unknown for C07K 16/30]
Applicants:
TXCELL [FR/FR]; Allée de la Nertière Les Cardoulines 06560 Valbonne, FR
Inventors:
ZHOU, Li; US
MEYER, François; CH
Agent:
ICOSA; 83 avenue Denfert-Rochereau 75014 Paris, FR
Priority Data:
17150579.506.01.2017EP
62/443,24206.01.2017US
Title (EN) MONOSPECIFIC REGULATORY T CELL POPULATION WITH CYTOTOXICITY FOR B CELLS
(FR) POPULATION DE LYMPHOCYTES T RÉGULATEURS MONOSPÉCIFIQUES AVEC CYTOTOXICITÉ POUR LES LYMPHOCYTES B
Abstract:
(EN) The present invention relates to a monospecific population of Treg cells, wherein the Treg cells comprise a chimeric receptor, wherein said chimeric receptor recognizes a B cell surface marker on a B cell, and wherein said Treg cells are cytotoxic for B cells. The present invention also relates to methods for obtaining said monospecific Treg cell population and to the use of said monospecific Treg cell population, in particular for treating an autoimmune disease.
(FR) La présente invention concerne une population monospécifique de lymphocytes Treg, les lymphocytes Treg comprenant un récepteur chimérique, ledit récepteur chimérique reconnaissant un marqueur de surface de lymphocytes B sur un lymphocytes B, et lesdits lymphocytes Treg étant cytotoxiques pour les lymphocytes B. La présente invention concerne également des procédés d'obtention de ladite population de lymphocytes Treg monospécifiques et l'utilisation de ladite population de lymphocytes Treg monospécifiques, en particulier pour le traitement d'une maladie auto-immune.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)