Search International and National Patent Collections

1. (WO2018127564) DETECTING AGENTS AND EPITOPES MAPPING FOR DETECTING GLYCOGEN PHOSPHORYLASE ISOENZYME BB

Pub. No.:    WO/2018/127564    International Application No.:    PCT/EP2018/050277
Publication Date: Fri Jul 13 01:59:59 CEST 2018 International Filing Date: Sat Jan 06 00:59:59 CET 2018
IPC: C07K 16/00
G01N 33/68
Applicants: DIAGENICS GROUP SE
Inventors: KAPETANOVIC, Ernest
YASTAS, Samir
Title: DETECTING AGENTS AND EPITOPES MAPPING FOR DETECTING GLYCOGEN PHOSPHORYLASE ISOENZYME BB
Abstract:
Described are an oligopeptide sequence of any of RDHLVGRWIR (E1), IRRFKSSKFGCR (E2), RHLEIIYAINQR (E3). LIIKLVT (E4), WGDRLKVIF (E5), any combination of E1 to E3; or combination of E4 and E5. Further described is a detecting agent for specific detecting glycogen phosphorylase iso-enzyme BB (GPBB), wherein the detecting agent is characterized by specific recognizing and binding to (1) an epitope of the GPBB comprising an oligo-peptide sequence of any of RDHLVGRWIR (E1), IRRFKSSKFGCR (E2), RHLEIIYAINQR (E3) or any combination of E1 to E3; or (2)an epitope of GPBB comprising an oiigo-peptide sequence of LIIKLVT (E4), and/or WGDRLKVIF (E5), or combination of E4 and E5.