Some content of this application is unavailable at the moment.
If this situation persist, please contact us atFeedback&Contact
1. (WO2018127544) USE OF RADICAL S-ADENOSYL METHIONINE (SAM) ENZYMES FOR INTRODUCING α-KETO-β3-AMINO ACIDS INTO (POLY)PEPTIDES
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/127544 International Application No.: PCT/EP2018/050225
Publication Date: 12.07.2018 International Filing Date: 05.01.2018
IPC:
C12N 9/10 (2006.01)
[IPC code unknown for C12N 9/10]
Applicants:
ETH ZURICH [CH/CH]; Raemistrasse 101 / ETH transfer 8092 Zurich, CH
Inventors:
PIEL, Jörn; CH
MORINAKA, Brandon; CH
Priority Data:
17150498.806.01.2017EP
Title (EN) USE OF RADICAL S-ADENOSYL METHIONINE (SAM) ENZYMES FOR INTRODUCING α-KETO-β3-AMINO ACIDS INTO (POLY)PEPTIDES
(FR) UTILISATION D’ENZYMES RADICALAIRES S-ADÉNOSYL MÉTHIONINES (SAM) POUR L’INTRODUCTION D’ACIDES Α-CÉTO-Β3-AMINÉS DANS DES (POLY)PEPTIDES
Abstract:
(EN) The present invention relates to the use of a radical S-adenosyl methionine (rSAM) enzyme in a method for introducing at least one α-keto-ß3-amino acid into (poly)peptide substrates comprising one or more of amino acid motif XYG, wherein X is any natural or non-natural amino acid, Y is tyrosine and G is glycine. Furthermore, the present invention relates to a method for introducing at least one α-keto-ß3-amino acid into (poly)-peptides comprising said XYG motif using a radical S-adenosyl methionine (rSAM) enzyme.
(FR) La présente invention concerne l’utilisation d’une enzyme radicalaire S-adénosyl méthionine (rSAM) dans un procédé d’introduction d’au moins un acide α-céto-β3-aminé dans des substrats (poly)peptidiques comprenant un ou plusieurs motifs acide aminé (XYG), X étant n’importe quel acide aminé d’origine naturelle ou synthétique, Y étant la tyrosine et G la glycine. En outre, la présente invention concerne un procédé d’introduction d’au moins un acide α-céto-β3-aminé dans des (poly)-peptides comprenant ledit motif (XYG) en utilisant une enzyme radicalaire S-adénosyl méthionine (rSAM).
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)