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1. (WO2018127526) SOLID FORMS OF [(1 S)-1 -[(2S,4R,5R)-5-(5-AMINO-2-OXO-THIAZOLO[4,5-D]PYRIMIDIN-3-YL)-4-HYDROXY-TE TRAHYDROFURAN-2-YL]PROPYL] ACETATE

Pub. No.:    WO/2018/127526    International Application No.:    PCT/EP2018/050160
Publication Date: Fri Jul 13 01:59:59 CEST 2018 International Filing Date: Fri Jan 05 00:59:59 CET 2018
IPC: C07D 513/04
A61K 31/519
A61P 31/12
Applicants: F. HOFFMANN-LA ROCHE AG
HOFFMANN-LA ROCHE INC.
Inventors: GROSSE-SENDER, Katja
SCHWITTER, Urs
STOWASSER, Frank
WANG, Xuemei
XIONG, Jing
Title: SOLID FORMS OF [(1 S)-1 -[(2S,4R,5R)-5-(5-AMINO-2-OXO-THIAZOLO[4,5-D]PYRIMIDIN-3-YL)-4-HYDROXY-TE TRAHYDROFURAN-2-YL]PROPYL] ACETATE
Abstract:
The present invention relates to novel solid forms of compound (I) [(1S)-1-[(2S,4R,5R)-5-(5-amino-2-oxo-thiazolo[4,5-d]pyrimidin-3-yl)-4-hydroxy-tetrahydrofuran-2-yl]propyl] acetate and pharmaceutical compositions comprising the solid forms thereof disclosed herein, which may be used as a TLR7 agonist, or for the treatment or prophylaxis of a viral disease in a patient relating to HBV infection or a disease caused by HBV infection.