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1. (WO2018127372) DETECTION OF TRANSIENT TROPONIN PEAKS FOR DIAGNOSIS OF SUBJECTS AT HIGH RISK OF CARDIOVASCULAR DISEASE

Pub. No.:    WO/2018/127372    International Application No.:    PCT/EP2017/082719
Publication Date: Fri Jul 13 01:59:59 CEST 2018 International Filing Date: Thu Dec 14 00:59:59 CET 2017
IPC: G01N 33/68
A61B 5/00
G06F 19/00
Applicants: WITTEMAN, Johanna Cornelia Maria
Inventors: WITTEMAN, Johanna Cornelia Maria
Title: DETECTION OF TRANSIENT TROPONIN PEAKS FOR DIAGNOSIS OF SUBJECTS AT HIGH RISK OF CARDIOVASCULAR DISEASE
Abstract:
The present invention provides a method to assess troponin peaks in a subject to estimate CHD risk, said method comprising a) fine-temporal serial testing in body fluid samples obtained from the subject the concentration of troponin; b) assessment of troponin peaks in a subject, wherein preferably an accumulative peak score is computed, and whereby peak height and peak frequency are indicative for the risk of CHD in the subject; c) the troponin peaks are assessed and corresponding CHD risk computed in an ongoing fashion; d) a clinical algorithm is used to determine an increased CHD risk in the subject. The present invention also provides a method to use above method to select a suitable therapy against CHD for the subject, to monitor treatment effectiveness and to guide treatment course in a subject. In an alternative, the assessment of troponin peaks will be performed in combination with the assessment of NT-proBNP peaks to estimate CHD risk.