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1. (WO2018126898) THIENOPYRIMIDINE DERIVATIVE, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF IN MANUFACTURING OF ANTITUMOR DRUGS

Pub. No.:    WO/2018/126898    International Application No.:    PCT/CN2017/117610
Publication Date: Fri Jul 13 01:59:59 CEST 2018 International Filing Date: Fri Dec 22 00:59:59 CET 2017
IPC: C07D 495/04
A61K 31/519
A61P 35/00
Applicants: HENAN METAB BIOPHARMA CO., LTD
河南美泰宝生物制药有限公司
Inventors: CHANG, Junbiao
常俊标
DU, Jinfa
杜锦发
Title: THIENOPYRIMIDINE DERIVATIVE, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF IN MANUFACTURING OF ANTITUMOR DRUGS
Abstract:
The present invention provides a thienopyrimidine derivative, a preparation method therefor, and an application thereof in manufacturing of antitumor drugs. The derivative has a structure as represented by general formula (I), comprising a single stereoisomer or racemic mixture thereof, wherein R is independently selected from hydrogen (H) or deuterium (D); R1 and R2 are independently selected from H, D, F, Cl, I, CN, and N3; when H is selected for R and R1 or R2, H cannot be selected for the other of R1 and R2; R3, R4, and R5 are independently selected from optionally substituted alkyl groups, cycloalkyl groups, heterocyclic groups, aromatic ring (Ar) groups, and heteroaromatic ring groups.