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|1. (WO2018126796) METHOD FOR PREPARING ANTI-BACTERIAL SURFACE ON MEDICAL MATERIAL SURFACE|
|Applicants:||SOUTH CHINA UNIVERSITY OF TECHNOLOGY
|Title:||METHOD FOR PREPARING ANTI-BACTERIAL SURFACE ON MEDICAL MATERIAL SURFACE|
Disclosed is a method for preparing an anti-bacterial surface on a medical material surface, comprising the steps of: (1) conducting chemical graft of amino silane after performing oxygen plasma pretreatment to the medical material surface and then reacting the medical material on the amino silane surface with an acyl compound; (2) placing the medical material with an initiator-modified surface into an anti-adhesion aqueous monomer solution for a graft polymerization reaction; (3) placing the medical material with an anti-adhesion polymer brush-modified surface into an azide compound-containing dimethylformamide solution; and (4) placing the medical material with an azide surface into an antibacterial agent click solution for a click reaction, obtaining an anti-adhesion polymer layer- and antibacterial agent layer-comodified antibacterial surface. The method prevents mutual interference of the anti-adhesion ability and bectericidal ability, and has good long-acting antibacterial performance.