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1. (WO2018126796) METHOD FOR PREPARING ANTI-BACTERIAL SURFACE ON MEDICAL MATERIAL SURFACE

Pub. No.:    WO/2018/126796    International Application No.:    PCT/CN2017/110895
Publication Date: Fri Jul 13 01:59:59 CEST 2018 International Filing Date: Wed Nov 15 00:59:59 CET 2017
IPC: A61L 31/16
A61L 31/14
A61L 31/10
C08F 292/00
Applicants: SOUTH CHINA UNIVERSITY OF TECHNOLOGY
华南理工大学
Inventors: REN, Li
任力
WANG, Lin
王琳
HE, Jingcai
何精才
WANG, Yingjun
王迎军
Title: METHOD FOR PREPARING ANTI-BACTERIAL SURFACE ON MEDICAL MATERIAL SURFACE
Abstract:
Disclosed is a method for preparing an anti-bacterial surface on a medical material surface, comprising the steps of: (1) conducting chemical graft of amino silane after performing oxygen plasma pretreatment to the medical material surface and then reacting the medical material on the amino silane surface with an acyl compound; (2) placing the medical material with an initiator-modified surface into an anti-adhesion aqueous monomer solution for a graft polymerization reaction; (3) placing the medical material with an anti-adhesion polymer brush-modified surface into an azide compound-containing dimethylformamide solution; and (4) placing the medical material with an azide surface into an antibacterial agent click solution for a click reaction, obtaining an anti-adhesion polymer layer- and antibacterial agent layer-comodified antibacterial surface. The method prevents mutual interference of the anti-adhesion ability and bectericidal ability, and has good long-acting antibacterial performance.