Some content of this application is unavailable at the moment.
If this situation persist, please contact us atFeedback&Contact
1. (WO2018126523) SYNTHESIS METHOD OF PROLINE-HISTIDINE CYCLODIPEPTIDE
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/126523 International Application No.: PCT/CN2017/075123
Publication Date: 12.07.2018 International Filing Date: 28.02.2017
IPC:
C07K 5/12 (2006.01) ,C07D 487/04 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
5
Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
04
containing only normal peptide links
12
Cyclic peptides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
Applicants:
陕西慧康生物科技有限责任公司 SHAANXI HUIKANG BIO-TECH CO., LTD [CN/CN]; 中国陕西省西安市 雁塔区雁翔路西安交通大学科技园保赛大厦四楼 4F, Bao Sai Building, Technology Park of Xi'an Jiaotong University Yan Xiang Road, Yanta District Xi'an, Shaanxi 710054, CN
Inventors:
王惠嘉 WANG, Huijia; CN
王慧 WANG, Hui; CN
苏晨灿 SU, Chencan; CN
张忠旗 ZHANG, Zhongqi; CN
李乾 LI, Qian; CN
王万科 WANG, Wanke; CN
高长波 GAO, Changbo; CN
郭添 GUO, Tian; CN
韩广 HAN, Guang; CN
赵金礼 ZHAO, Jinli; CN
杨小琳 YANG, Xiaolin; CN
Agent:
北京市浩天知识产权代理事务所(普通合伙) HYLANDS LAW FIRM; 中国北京市 朝阳区朝阳门外大街18号丰联广场A座15层1511 Unit 1511, 15/F, Tower A, Full Link Plaza No. 18 Chaoyangmenwai Ave. Chaoyang District Beijing 100020, CN
Priority Data:
201710004723204.01.2017CN
Title (EN) SYNTHESIS METHOD OF PROLINE-HISTIDINE CYCLODIPEPTIDE
(FR) PROCÉDÉ DE SYNTHÈSE DE CYCLODIPEPTIDE PROLINE-HISTIDINE
(ZH) 脯组环二肽的合成方法
Abstract:
(EN) The invention provides a synthesis method of a proline-histidine cyclodipeptide, comprising: preparing an amino-protected proline-histidine dipeptide methyl ester from histidine and proline, wherein one of histidine and valine is a methyl ester hydrochloride form, the other is an amino protected form; deprotecting the amino-protected proline-histidine dipeptide methyl ester and ring synthesizing the proline-histidine cyclodipeptide.
(FR) L'invention concerne un procédé de synthèse d'un cyclodipeptide proline-histidine, consistant à : préparer un ester méthylique dipeptide de proline-histidine à protection amino à partir d'histidine et de proline, l'une de l'histidine et de la valine étant une forme d'hydrochlorure d'ester méthylique, l'autre étant une forme à protection amino ; déprotéger l'ester méthylique dipeptide de proline-histidine à protection amino et synthétiser de manière cyclique le cyclodipeptide de proline-histidine.
(ZH) 提供了一种脯组环二肽的合成方法,包括:由组氨酸和脯氨酸制备氨基被保护的脯组二肽甲酯,其中组氨酸和脯氨酸中的一种是甲酯盐酸盐的形式,另一种是氨基被保护的形式;将氨基被保护的脯组二肽甲酯脱保护并环合成脯组环二肽。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)