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1. (WO2018126316) VEGFR-2 ANTIBODIES

Pub. No.:    WO/2018/126316    International Application No.:    PCT/CA2018/050003
Publication Date: Fri Jul 13 01:59:59 CEST 2018 International Filing Date: Fri Jan 05 00:59:59 CET 2018
IPC: C07K 16/28
A61K 39/395
A61K 47/68
A61K 49/00
A61P 35/00
C07K 16/30
C12N 15/13
Applicants: HELIX BIOPHARMA CORPORATION
Inventors: CHAO, Heman
WONG, Wah Yau
TIAN, Baomin
UGER, Marni Diane
Title: VEGFR-2 ANTIBODIES
Abstract:
Antibodies for tumor treatment are provided. More particularly are provided anti- VEGFR-2 antibodies, fragments and variants thereof that can be used for example, to inhibit/decrease angiogenesis and thus induce tumor regression in VEGFR-2 expressing tumors. In aspects, single domain anti-VEGFR-2 antibodies, fragments and variants thereof are provided to inhibit/decrease angiogenesis and induce tumor regression.