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|1. (WO2018126315) ANTI-VEGFR-2 UREASE CONJUGATES|
|Applicants:||HELIX BIOPHARMA CORPORATION
WONG, Wah Yau
UGER, Marni Diane
|Title:||ANTI-VEGFR-2 UREASE CONJUGATES|
Antibody-urease conjugates having therapeutic utility are provided. More specifically, described herein are anti-VEGFR-2 antibody-urease conjugates for the treatment of solid tumors. A conjugate comprising an anti-VEGFR-2 antibody moiety conjugated to a urease moiety is described. Compositions and methods are also described for the treatment of VEGFR-2 dependent tumors, incorporating the antibody-urease conjugates described herein.