Search International and National Patent Collections

1. (WO2018126315) ANTI-VEGFR-2 UREASE CONJUGATES

Pub. No.:    WO/2018/126315    International Application No.:    PCT/CA2018/050002
Publication Date: Fri Jul 13 01:59:59 CEST 2018 International Filing Date: Fri Jan 05 00:59:59 CET 2018
IPC: C07K 19/00
A61K 47/68
A61K 9/19
A61P 35/00
C07K 16/28
C12N 9/78
Applicants: HELIX BIOPHARMA CORPORATION
Inventors: CHAO, Heman
WONG, Wah Yau
TIAN, Baomin
UGER, Marni Diane
Title: ANTI-VEGFR-2 UREASE CONJUGATES
Abstract:
Antibody-urease conjugates having therapeutic utility are provided. More specifically, described herein are anti-VEGFR-2 antibody-urease conjugates for the treatment of solid tumors. A conjugate comprising an anti-VEGFR-2 antibody moiety conjugated to a urease moiety is described. Compositions and methods are also described for the treatment of VEGFR-2 dependent tumors, incorporating the antibody-urease conjugates described herein.