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1. (WO2018126282) IMMUNOMODULATORY ONCOLYTIC ADENOVIRAL VECTORS, AND METHODS OF PRODUCTION AND USE THEREOF FOR TREATMENT OF CANCER
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Pub. No.: WO/2018/126282 International Application No.: PCT/US2018/012113
Publication Date: 05.07.2018 International Filing Date: 02.01.2018
IPC:
A61K 48/00 (2006.01) ,A61K 35/761 (2015.01) ,C12N 15/861 (2006.01) ,C12N 15/86 (2006.01)
[IPC code unknown for A61K 48][IPC code unknown for A61K 35/761][IPC code unknown for C12N 15/861][IPC code unknown for C12N 15/86]
Applicants:
TRIEZA THERAPEUTICS, INC. [US/US]; 1030 Massachusetts Avenue #210 Cambridge, MA 02138, US
Inventors:
HICKLIN, Daniel; US
WILLS, Kenneth, Nelson; US
SEIDEL-DUGAN, Cynthia; US
WINSTON, William; US
STEINER, Philipp; US
Agent:
KABLER, Kevin; US
WHITEHEAD, Andrew, P.; US
SHUSTER, Michael, J.; US
HUBL, Susan, T.; US
KINCH, Mark; US
Priority Data:
15/834,69007.12.2017US
62/440,64630.12.2016US
62/440,67030.12.2016US
62/572,20613.10.2017US
Title (EN) IMMUNOMODULATORY ONCOLYTIC ADENOVIRAL VECTORS, AND METHODS OF PRODUCTION AND USE THEREOF FOR TREATMENT OF CANCER
(FR) VECTEURS ADÉNOVIRAUX ONCOLYTIQUES IMMUNOMODULATEURS, ET LEURS PROCÉDÉS DE PRODUCTION ET D'UTILISATION POUR LE TRAITEMENT DU CANCER
Abstract:
(EN) Disclosed herein are compositions and methods for treating cancer in a subject. This involves administering an oncolytic virus containing a heterologous DNA sequence encoding one or more immunomodulatory and/or immunostimulatory polypeptide(s) of interest to the subject under conditions effective to enhance an anti-tumor immune response in the subject, and to treat cancer. It also relates to a method of enhancing the delivery to and distribution within a tumor mass of therapeutic viruses.
(FR) L'invention porte sur des compositions et des méthodes de traitement d'un cancer chez un sujet. Ceci implique à administrer au sujet un virus oncolytique contenant une séquence d'ADN hétérologue codant pour un ou plusieurs polypeptides immunomodulateurs et/ou immunostimulateurs d'intérêt dans des conditions efficaces pour améliorer une réponse immunitaire antitumorale chez le sujet, et pour traiter le cancer. L'invention concerne également un procédé d'amélioration de l'administration et de la distribution de virus thérapeutiques dans une masse tumorale.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)