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|1. (WO2018126233) ANTI-HUMAN TIM-3 ANTIBODIES AND METHODS OF USE THEREOF|
|Applicants:||DEVELOPMENT CENTER FOR BIOTECHNOLOGY
|Title:||ANTI-HUMAN TIM-3 ANTIBODIES AND METHODS OF USE THEREOF|
An anti-human T-cell immunoglobulin domain and mucin domain 3 (TIM-3) antibody, can bind the peptides, comprising the amino-acid sequence RKGDVSL (SEQ ID NO: 9) and/or EKFNLKL (SEQ ID NO: 10) of human TIM-3 protein. The antibody can regulate immune cell activity. The antibody or binding fragment thereof is useful in diagnosis, prognosis, and treatment of cancers that have been reported to express cell-surface TIM-3 such as lung, liver, esophageal cancer and solid tumors.