Search International and National Patent Collections

1. (WO2018126233) ANTI-HUMAN TIM-3 ANTIBODIES AND METHODS OF USE THEREOF

Pub. No.:    WO/2018/126233    International Application No.:    PCT/US2017/069140
Publication Date: Fri Jul 06 01:59:59 CEST 2018 International Filing Date: Sun Dec 31 00:59:59 CET 2017
IPC: A61K 39/395
A61P 35/00
C07K 16/28
C12N 15/13
Applicants: DEVELOPMENT CENTER FOR BIOTECHNOLOGY
DCB-USA LLC
Inventors: YANG, Yu-Chen
CHEN, Li-Yu
LI, Chia-Hua
TAI, Pei-Han
CHEN, Hong-Kai
LOK, Ying-Yung
HU, Chih-Yung
KUAN, Chien-Tsun
WU, Chung-Hsiun
Title: ANTI-HUMAN TIM-3 ANTIBODIES AND METHODS OF USE THEREOF
Abstract:
An anti-human T-cell immunoglobulin domain and mucin domain 3 (TIM-3) antibody, can bind the peptides, comprising the amino-acid sequence RKGDVSL (SEQ ID NO: 9) and/or EKFNLKL (SEQ ID NO: 10) of human TIM-3 protein. The antibody can regulate immune cell activity. The antibody or binding fragment thereof is useful in diagnosis, prognosis, and treatment of cancers that have been reported to express cell-surface TIM-3 such as lung, liver, esophageal cancer and solid tumors.