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1. (WO2018126229) POLYPEPTIDE-ANTIGEN CONJUGATES WITH NON-NATURAL AMINO ACIDS
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Pub. No.: WO/2018/126229 International Application No.: PCT/US2017/069129
Publication Date: 05.07.2018 International Filing Date: 29.12.2017
IPC:
A61K 39/09 (2006.01) ,A61K 47/64 (2017.01) ,A61P 31/04 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
02
Bacterial antigens
09
Streptococcus
[IPC code unknown for A61K 47/64]
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04
Antibacterial agents
Applicants:
SUTROVAX, INC. [US/US]; 353 Hatch Drive Foster City, California 94404, US
Inventors:
FAIRMAN, Jeff; US
HEINRICHS, Jon; US
CHAN, Wei; US
Agent:
REED, Dianne E.; US
Priority Data:
62/441,11530.12.2016US
62/530,80310.07.2017US
62/568,20104.10.2017US
62/591,16027.11.2017US
Title (EN) POLYPEPTIDE-ANTIGEN CONJUGATES WITH NON-NATURAL AMINO ACIDS
(FR) CONJUGUÉS POLYPEPTIDE-ANTIGÈNE AVEC DES ACIDES AMINÉS NON NATURELS
Abstract:
(EN) Methods for the production of immunogenic compositions containing a non-natural amino acid are disclosed. The non-natural amino acid can be a site for attachment of antigens, such as bacterial capsular polysaccharides, to make immunogenic conjugates. Bio-orthogonal attachment chemistry incorporated into the non-natural amino acids allows for more efficient and potent antigen presentation to the immune system, simplified purification, and more well-defined structure of these semi-synthetic immunogens.
(FR) L'invention concerne des procédés de production de compositions immunogènes contenant un acide aminé non naturel. L'acide aminé non naturel peut être un site pour la fixation d'antigènes, tels que des polysaccharides capsulaires bactériens, pour produire des conjugués immunogènes. La chimie de fixation bio-orthogonale incorporée dans les acides aminés non naturels permet une présentation de l'antigène plus efficace et puissante au système immunitaire, une purification simplifiée et une structure mieux définie de ces immunogènes semi-synthétiques.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)