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1. (WO2018126131) PUMPLESS MICROFLUIDIC ORGAN-ON-A-CHIP SYSTEM INCLUDING A FUNCTIONAL IMMUNE SYSTEM

Pub. No.:    WO/2018/126131    International Application No.:    PCT/US2017/068952
Publication Date: Fri Jul 06 01:59:59 CEST 2018 International Filing Date: Sat Dec 30 00:59:59 CET 2017
IPC: B01L 3/00
C12M 3/00
G01N 33/483
Applicants: UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC.
HESPEROS, INC.
Inventors: HICKMAN, James
COLON, Alisha
MCALEER, Christopher
SASSARTH, Trevor
RUMSEY, John
ELBRECHT, Daniel
Title: PUMPLESS MICROFLUIDIC ORGAN-ON-A-CHIP SYSTEM INCLUDING A FUNCTIONAL IMMUNE SYSTEM
Abstract:
A pumpless microfluidic system is disclosed that can be used to mimic the interaction of organ systems with the immune system. Also disclosed is a method for mimicking an immune system, comprising culturing a plurality of organ cells and at least one population of immune cells in the disclosed pumpless microfluidic system under physiological conditions. The method can further comprise activating an immune reaction in the pumpless microfluidic system, continuing the culture for a defined period, collecting a sample of culture medium from the system, and assaying the sample for one or more indicators of an immune response.