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1. (WO2018125970) SYNTHETIC ADENOVIRUSES TARGETING BONE TISSUE AND USES THEREOF
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Pub. No.: WO/2018/125970 International Application No.: PCT/US2017/068652
Publication Date: 05.07.2018 International Filing Date: 28.12.2017
IPC:
C12N 15/861 (2006.01) ,A61K 48/00 (2006.01) ,A61P 19/08 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79
Vectors or expression systems specially adapted for eukaryotic hosts
85
for animal cells
86
Viral vectors
861
Adenoviral vectors
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19
Drugs for skeletal disorders
08
for bone diseases, e.g. rachitism, Paget's disease
Applicants:
SALK INSTITUTE FOR BIOLOGICAL STUDIES [US/US]; 10010 N. Torrey Pines Road La Jolla, CA 92037-1002, US
Inventors:
POWERS, Colin; US
O'SHEA, Clodagh; US
ZHANG, Lei; US
Agent:
CONNOLLY, Jodi, L.; US
Priority Data:
62/440,97230.12.2016US
Title (EN) SYNTHETIC ADENOVIRUSES TARGETING BONE TISSUE AND USES THEREOF
(FR) ADÉNOVIRUS SYNTHÉTIQUES CIBLANT UN TISSU OSSEUX ET UTILISATIONS CORRESPONDANTES
Abstract:
(EN) Synthetic adenoviruses with tropism to bone tissue are described. The synthetic adenoviruses include an adenovirus type 11 (Adl 1) fiber protein or a chimeric adenovirus fiber protein having an Adl 1 knob domain. The synthetic adenoviruses can also include a transgene, such as a reporter gene or a transgene encoding a factor that promotes bone regeneration or repair. Use of the synthetic adenoviruses to target bone tissue and/or to promote bone repair or regeneration is also described.
(FR) L'invention concerne des adénovirus synthétiques présentant un tropisme vis-à-vis du tissu osseux. Les adénovirus synthétiques comprennent une protéine fibreuse de type 11 d'adénovirus (Adl 1) ou une protéine fibreuse d'adénovirus chimérique présentant un domaine de bouton Adl 1. Les adénovirus synthétiques peuvent également comprendre un transgène, tel qu'un gène rapporteur ou un transgène codant pour un facteur qui favorise la régénération osseuse ou la réparation osseuse. L'invention concerne également l'utilisation des adénovirus synthétiques pour cibler un tissu osseux et/ou pour favoriser la réparation osseuse ou la régénération osseuse.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)