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1. (WO2018125964) MODIFIED CRISPR RNA AND USES THEREOF

Pub. No.:    WO/2018/125964    International Application No.:    PCT/US2017/068642
Publication Date: Fri Jul 06 01:59:59 CEST 2018 International Filing Date: Fri Dec 29 00:59:59 CET 2017
IPC: C12N 15/11
C12P 19/34
C07H 21/02
Applicants: IONIS PHARMACEUTICALS, INC.
LUDWIG INSTITUTE FOR CANCER RESEARCH
Inventors: RAHDAR, Meghdad
PRAKASH, Thazha, P.
SWAYZE, Eric, E.
BENNETT, C., Frank
MCMAHON, Moira, A.
Title: MODIFIED CRISPR RNA AND USES THEREOF
Abstract:
The present disclosure provides compounds comprising modified oligonucleotides for use in CRISPR. In certain embodiments, such modified oligonucleotides provide improved properties of crRNA.