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1. (WO2018125832) MULTI-STAGE SAMPLE RECOVERY SYSTEM

Pub. No.:    WO/2018/125832    International Application No.:    PCT/US2017/068296
Publication Date: Fri Jul 06 01:59:59 CEST 2018 International Filing Date: Sat Dec 23 00:59:59 CET 2017
IPC: C04B 30/00
C40B 60/12
G01N 35/00
G01N 35/10
Applicants: XCELLA BIOSCIENCES, INC.
Inventors: CHEN, Bob
Title: MULTI-STAGE SAMPLE RECOVERY SYSTEM
Abstract:
Multi-stage sample-recovery systems, including automated 2-stage and 3- stage sample-recovery systems, are provided. Such systems enable the rapid screening and recovery of samples, including viable cell-based samples, from high- throughput screening systems, including systems utilizing large-scale arrays of microcapillaries. In specific screening systems, each microcapillary comprises a solution containing a variant protein, an immobilized target molecule, and a reporter element. Immobilized target molecules may include any molecule of interest, including proteins, nucleic acids, carbohydrates, and other biomolecules. The association of a variant protein with a molecular target is assessed by measuring a signal from the reporter element. The contents of microcapillaries identified in the assays as containing variant proteins of interest can be identified and recovered using the multi-stage systems disclosed herein.