Search International and National Patent Collections

1. (WO2018125716) MORPHINAN DERIVATIVES AND USE THEREOF

Pub. No.:    WO/2018/125716    International Application No.:    PCT/US2017/067611
Publication Date: Fri Jul 06 01:59:59 CEST 2018 International Filing Date: Thu Dec 21 00:59:59 CET 2017
IPC: C07D 489/02
A61K 31/485
A61P 25/04
Applicants: PURDUE PHARMA L.P.
Inventors: TAFESSE, Laykea
Title: MORPHINAN DERIVATIVES AND USE THEREOF
Abstract:
The application is directed to compounds of formula (I): and pharmaceutically acceptable salts, radiolabeled isomers, solvates, or hydrates thereof, wherein R1, R2, R3, X, and n are defined as set forth in the specification. The application is also directed to compounds of formulae II, I-a, I-al, I-a2, I-b, and I-b1 and the pharmaceutically acceptable salts, radiolabeled isomers, solvates, and hydrates thereof. The application is also directed to use of Compounds of the present disclosure to treat disorders responsive to the modulation of one or more opioid receptors, or as synthetic intermediates. Certain Compounds of the present disclosure are especially useful for treating pain. In one embodiment, Compounds of the present disclosure exhibit less opioid-induced side effects (such as, euphoria or drug-liking).