Search International and National Patent Collections

1. (WO2018125589) TREATMENT OF ADVANCED HER2 EXPRESSING CANCER

Pub. No.:    WO/2018/125589    International Application No.:    PCT/US2017/066286
Publication Date: Fri Jul 06 01:59:59 CEST 2018 International Filing Date: Fri Dec 15 00:59:59 CET 2017
IPC: C07K 16/32
A61K 39/395
Applicants: GENENTECH, INC.
F. HOFFMANN-LA ROCHE AG
Inventors: BEATTIE, Mary
BRAMMER, Melissa
Title: TREATMENT OF ADVANCED HER2 EXPRESSING CANCER
Abstract:
Methods for the treatment of patients with HER2-positive, HER2-amplified and/or HER2-mutated advanced cancer by administration of pertuzumab plus trastuzumab are disclosed. In one aspect, the cancer is advanced HER2-positive, HER2-amplified and/or HER2-mutated colorectal, biliary, bladder, urothelial, salivary, lung, pancreatic, ovarian, prostate, or skin cancer. In another aspect, the cancer is HER2-positive, HER2-amplified and/or HER2-mutated colorectal, biliary, bladder, urothelial, salivary, lung, pancreatic, ovarian, prostate, or skin cancer that is refractory to one or more other treatment regimens.