Aspects of the embodiments are directed to calibrating a cross-talk cancellation module. A data eye response for a first data channel can be acquired, and the left-side and right-side maximum transition edges can be determined while adjacent data channels are silent. The adjacent data channels can be activated, first using an even mode waveform. A strobe can be positioned at the left-side maximum boundary in anticipation of a right-shift due to even mode waveform cross talk. A summer circuit can sum the waveform from the first data channel with cross-talk induced voltage pulse having an opposite polarity from the even mode waveforms on the aggressor channels. A left-side edge can be determined by incrementally adjusting gain and detector parameters. These parameters can be locked once a left-side transition edge is located. The process can be repeated for a right-side transition edge with odd-mode aggressor waveforms.