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1. (WO2018124948) AQUEOUS PHARMACEUTICAL COMPOSITION OF A RECOMBINANT MONOCLONAL ANTIBODY TO TNFα

Pub. No.:    WO/2018/124948    International Application No.:    PCT/RU2017/050133
Publication Date: Fri Jul 06 01:59:59 CEST 2018 International Filing Date: Sat Dec 30 00:59:59 CET 2017
IPC: A61K 39/395
A61P 37/00
Applicants: JOINT STOCK COMPANY "BIOCAD"
ЗАКРЫТОЕ АКЦИОНЕРНОЕ ОБЩЕСТВО «БИОКАД»
Inventors: LOMKOVA, Ekaterina Aleksandrovna
ЛОМКОВА, Екатерина Александровна
IAKOVLEV, Aleksandr Olegovich
ЯКОВЛЕВ, Александр Олегович
SHITIKOVA, Viktoriya Olegovna
ШИТИКОВА, Виктория Олеговна
RYAKHOVSKAYA, Anastasiya Mikhajlovna
РЯХОВСКАЯ, Анастасия Михайловна
MOROZOV, Dmitry Valentinovich
МОРОЗОВ, Дмитрий Валентинович
Title: AQUEOUS PHARMACEUTICAL COMPOSITION OF A RECOMBINANT MONOCLONAL ANTIBODY TO TNFα
Abstract:
The invention relates to improved aqueous pharmaceutical compositions of a recombinant monoclonal antibody to TNFα, and to a method for producing same. The present invention also relates to the use of improved aqueous pharmaceutical compositions of a recombinant monoclonal antibody to TNFα to treat TNFα-mediated diseases. The proposed invention allows prevention of physical-chemical instability expressed in the formation of aggregates and fragments of proteins or in the modification of proteins in a solution, and also prevents instability during freezing/thawing, agitating and shaking.