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1. (WO2018124859) METHOD OF CONDITIONING A DONOR HEART

Pub. No.:    WO/2018/124859    International Application No.:    PCT/KZ2016/000019
Publication Date: Fri Jul 06 01:59:59 CEST 2018 International Filing Date: Sat Dec 03 00:59:59 CET 2016
IPC: A01N 1/02
Applicants: JOINT STOCK COMPANY "NATIONAL RESEARCH CARDIACSURGERY CENTER"
АКЦИОНЕРНОЕ ОБЩЕСТВО «НАЦИОНАЛЬНЫЙ НАУЧНЫЙ КАРДИОХИРУРГИЧЕСКИЙ ЦЕНТР»
Inventors: PYA, Yuriy Vladimirovich
ПЯ, Юрий Владимирович
KALIYEV, Rymbay Bolatovich
КАЛИЕВ, Рымбай Болатович
BEKBOSSYNOV, Serik Temirkhanovich
БЕКБОСЫНОВ, Серик Темирханович
LESBEKOV, Timur Dostaevich
ЛЕСБЕКОВ, Тимур Достаевич
NURMYKHAMETOVA, Zhuldyz Askarovna
НУРМЫХАМЕТОВА, Жулдыз Аскаровна
SMAGULOV, Nurlan Kuandykovich
СМАГУЛОВ, Нурлан Куандыкович
NOVIKOVA, Svetlana Petrovna
НОВИКОВА, Светлана Петровна
IBRAYEV, Talgat Ergalievich
ИБРАЕВ, Талгат Ергалиевич
ASHYROV, Zhanybek Zaydinovich
АШИРОВ, Жанибек Зайдинович
FAIZOV, Linar Rinatovich
ФАИЗОВ, Линар Ринатович
Title: METHOD OF CONDITIONING A DONOR HEART
Abstract:
The invention relates to medicine, and more particularly to cardiac surgery and cardiopulmonary bypass. The aim of the present invention is to improve heart transplantation results by optimizing the conditioning of a heart by the method described. A method of conditioning a donor heart comprises a set of measures that include the use of a blood cardioplegic solution, ultrafiltration, and Levosimendan. For cardioplegia in the body of the donor, a normothermic solution consisting of donor blood and a crystalloid solution in a 5:1 ratio (potassium chloride 4%, magnesium sulfate 25%, lidocaine 2%, sodium bicarbonate and mannitol 15%) is used. To protect the myocardium and improve its circulation, a single dose of Levosimendan (45 μg/kg) is introduced into the perfusate. To remove inflammatory mediators and excess fluid, and to correct the electrolyte composition and hematocrit, the perfusate is ultrafiltered. Prior to transplantation to the recipient, a blood cardioplegic solution is introduced to disconnect the donor heart from the OCS.