Some content of this application is unavailable at the moment.
If this situation persist, please contact us atFeedback&Contact
1. (WO2018124758) COMPOUND BEARING BETA-GALACTOSIDE-INTRODUCED SELF-IMMOLATIVE LINKER
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/124758 International Application No.: PCT/KR2017/015613
Publication Date: 05.07.2018 International Filing Date: 28.12.2017
IPC:
A61K 47/68 (2017.01) ,A61K 47/26 (2006.01)
[IPC code unknown for A61K 47/68]
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
06
Organic compounds
26
Carbohydrates
Applicants:
주식회사 인투셀 INTOCELL INC. [KR/KR]; 대전시 대덕구 문평서로 8-26 8-26, Munpyeongseo-ro Daedeok-gu Daejeon 34302, KR
Inventors:
박태교 PARK, Tae Kyo; KR
우성호 WOO, Sung Ho; KR
김선영 KIM, Sun Young; KR
정두환 JUNG, Doo Hwan; KR
이상광 LEE, Sang Kwang; KR
조종운 CHO, Jong Un; KR
이재호 LEE, Jae Ho; KR
박수호 PARK, Su Ho; KR
서동훈 SEO, Dong Hoon; KR
이향숙 LEE, Hyang Sook; KR
서범석 SEO, Beom Seok; KR
임지연 LIM, Ji Yeon; KR
Agent:
특허법인 플러스 PLUS INTERNATIONAL IP LAW FIRM; 대전시 서구 한밭대로 809 10층 10F, 809, Hanbat-daero Seo-gu Daejeon 35209, KR
Priority Data:
10-2016-018062828.12.2016KR
10-2017-018141127.12.2017KR
Title (EN) COMPOUND BEARING BETA-GALACTOSIDE-INTRODUCED SELF-IMMOLATIVE LINKER
(FR) COMPOSÉ PORTANT UN LIEUR AUTO-IMMOLABLE À BÊTA-GALACTOSIDE INTRODUIT
(KO) 베타-갈락토사이드가 도입된 자가-희생 기를 포함하는 화합물
Abstract:
(EN) The present invention relates to a compound bearing a self-immolative linker having β-galactoside introduced thereto. In a compound bearing a β-galactoside-introduced self-immolative linker according to the present invention, particularly, the self-immolative linker may form a glycosidic bond with a protein (e.g., an oligopeptide, a polypeptide, an antibody, etc.) or ligand which has specific affinity for a desired target or with an active agent (e.g., a drug, a toxin, a ligand, a detection probe, etc.) which has a specific function or activity so as to allow the selective release of the active agent within a target cell.
(FR) La présente invention concerne un composé portant un lieur auto-immolable dans lequel du bêta-galactoside est introduit. Dans un composé portant un lieur auto-immolable à bêta-galactoside introduit selon la présente invention, en particulier, le lieur auto-immolable peut former une liaison glycosidique avec une protéine (par exemple, un oligopeptide, un polypeptide, un anticorps, etc.) ou un ligand qui a une affinité spécifique pour une cible souhaitée ou avec un agent actif (par exemple, un médicament, une toxine, un ligand, une sonde de détection, etc.) qui a une fonction ou une activité spécifique de façon à permettre la libération sélective de l'agent actif à l'intérieur d'une cellule cible.
(KO) 본 발명은 β-갈락토사이드(β-galactoside)가 도입된 자가-희생 기(self-immolative linker)를 포함하는 화합물에 관한 것으로, 보다 상세하게는 본 발명의 β-갈락토사이드가 도입된 자가-희생 기를 포함하는 화합물은 목적하는 표적에 대한 결합 특이성을 갖는 단백질(예: 올리고펩티드, 폴리펩티드, 항체 등) 또는 리간드, 특이적 기능 또는 활성을 갖는 활성제(예: 약물, 독소, 리간드, 검출용 탐침 등) 및 타겟 세포내에서 선택적으로 활성제가 방출될 수 있도록 글라이코사이드 결합(glycosidic bond)을 이루고 있는 자가-희생 기를 포함할 수 있다.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Korean (KO)
Filing Language: Korean (KO)