WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Options
Query Language
Stem
Sort by:
List Length
Some content of this application is unavailable at the moment.
If this situation persist, please contact us atFeedback&Contact
1. (WO2018124744) METHOD FOR DIAGNOSING LIVER DISEASE VIA BACTERIAL METAGENOMIC ANALYSIS
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/124744 International Application No.: PCT/KR2017/015578
Publication Date: 05.07.2018 International Filing Date: 27.12.2017
IPC:
C12Q 1/68 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
Applicants: MD HEALTHCARE INC.[KR/KR]; (Sangam-dong,Woori Technology Bldg.) #1303, 9, World Cup buk-ro 56-gil, Mapo-gu, Seoul 03923, KR
Inventors: KIM, Yoon-Keun; KR
PARK, Taesung; KR
YOON, Jung-Hwan; KR
LEEM, Sangseob; KR
Agent: LEE, Myoung-Jin; KR
Priority Data:
10-2016-018148328.12.2016KR
10-2017-002500024.02.2017KR
10-2017-018004426.12.2017KR
Title (EN) METHOD FOR DIAGNOSING LIVER DISEASE VIA BACTERIAL METAGENOMIC ANALYSIS
(FR) PROCÉDÉ DE DIAGNOSTIC D'UNE MALADIE HÉPATIQUE PAR ANALYSE MÉTAGÉNOMIQUE BACTÉRIENNE
(KO) 세균 메타게놈 분석을 통한 간질환 진단 방법
Abstract:
(EN) The present invention relates to a method for diagnosing a liver disease, such as liver cancer and cirrhosis, via bacterial metagenomic analysis and, more particularly, to a method for diagnosing liver cancer and cirrhosis by performing bacterial metagenomic analysis using a subject-derived sample, and by analyzing an increase or decrease in the content of a specific bacterium-derived extracellular vesicle. An extracellular vesicle secreted from a bacterium present in the environment can be absorbed into the body and directly affect the occurrence of inflammation and cancer, and a liver disease, such as liver cancer and cirrhosis, is difficult to diagnose early on before any symptom appears, which makes efficient treatment difficult. As such, through the metagenomic analysis on a gene present in a bacterium-derived extracellular vesicle using a human body-derived sample according to the present invention, the risk of the onset of liver cancer and cirrhosis can be predicted in advance, enabling early diagnosis and prediction of a liver disease risk group and delay of the time of the onset or prevention of the onset through proper care, and early diagnosis is still possible even after the onset of cirrhosis or liver cancer, which can lower the incidence rate of the liver disease and enhance the treatment effect.
(FR) La présente invention concerne un procédé de diagnostic d'une maladie hépatique, telle qu'un cancer du foie et une cirrhose, par analyse métagénomique bactérienne et, plus particulièrement, un procédé de diagnostic du cancer du foie et de la cirrhose par la réalisation d'une analyse métagénomique bactérienne à l'aide d'un échantillon dérivé d'un sujet et par l'analyse d'une augmentation ou d'une diminution de la teneur en une vésicule extracellulaire dérivée d'une bactérie spécifique. Une vésicule extracellulaire sécrétée par une bactérie présente dans l'environnement peut être absorbée dans le corps et influencer directement l'apparition d'une inflammation et d'un cancer et le diagnostic précoce d'une maladie hépatique, telle qu'un cancer du foie et une cirrhose, est difficile avant l'apparition d'un quelconque symptôme, ce qui complique un traitement efficace. Ainsi, par l'intermédiaire de l'analyse métagénomique sur un gène présent dans une vésicule extracellulaire dérivée d'une bactérie à l'aide d'un échantillon dérivé du corps humain selon la présente invention, le risque d'apparition d'un cancer du foie et d'une cirrhose peut être prédit à l'avance, ce qui permet un diagnostic précoce et la prédiction d'un groupe à risque de maladie hépatique et de retarder le moment d'apparition ou de prévenir l'apparition par des soins appropriés et un diagnostic précoce est encore possible même après l'apparition de la cirrhose ou du cancer du foie, ce qui peut abaisser le taux d'incidence de la maladie hépatique et améliorer l'effet de traitement.
(KO) 본 발명은 세균 메타게놈 분석을 통해 간암 및 간경변 등의 간질환을 진단하는 방법에 관한 것으로서, 보다 구체적으로는 피검체 유래 샘플을 이용해 세균 메타게놈 분석을 수행하여 특정 세균 유래 세포밖 소포의 함량 증감을 분석함으로써 간암 및 간경변을 진단하는 방법에 관한 것이다. 환경에 존재하는 세균에서 분비되는 세포밖 소포는 체내에 흡수되어 염증 및 암 발생에 직접적인 영향을 미칠 수 있으며, 간암 및 간경변 등의 간질환은 증상이 나타나기 전 조기진단이 어려워 효율적인 치료가 어려운 실정이므로, 본 발명에 따른 인체 유래 샘플을 이용한 세균 유래 세포밖 소포에 존재하는 유전자에 대하여 메타게놈 분석을 통해 간암 및 간경변 발병의 위험도를 미리 예측함으로써 간질환의 위험군을 조기에 진단 및 예측하여 적절한 관리를 통해 발병 시기를 늦추거나 발병을 예방할 수 있으며, 간경변 혹은 간암 발병 후에도 조기진단 할 수 있어 간질환의 발병률을 낮추고 치료효과를 높일 수 있다.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Korean (KO)
Filing Language: Korean (KO)