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1. WO2018124700 - NOVEL PREPARATION CONTAINING BENZIMIDAZOLE DERIVATIVE

Publication Number WO/2018/124700
Publication Date 05.07.2018
International Application No. PCT/KR2017/015489
International Filing Date 26.12.2017
IPC
A61K 9/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
A61K 47/38 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
38Cellulose; Derivatives thereof
A61K 47/36 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
A61K 31/4184 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
41641,3-Diazoles
4184condensed with carbocyclic rings, e.g. benzimidazoles
CPC
A61K 31/4184
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
41641,3-Diazoles
4184condensed with carbocyclic rings, e.g. benzimidazoles
A61K 47/36
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
A61K 47/38
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
38Cellulose; Derivatives thereof
A61K 9/0053
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0012Galenical forms characterised by the site of application
0053Mouth and digestive tract, i.e. intraoral and peroral administration
A61K 9/2009
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, tablets, ; discs, rods
2004Excipients; Inactive ingredients
2009Inorganic compounds
A61K 9/2027
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, tablets, ; discs, rods
2004Excipients; Inactive ingredients
2022Organic macromolecular compounds
2027obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
Applicants
  • 씨제이헬스케어 주식회사 CJ HEALTHCARE CORPORATION [KR]/[KR]
Inventors
  • 임형석 LIM, Hyungsuk
  • 류춘선 LYU, Chun Seon
  • 박선영 PARK, Sun Young
  • 신경민 SHIN, Kyungmin
  • 오다원 OH, Da Won
Agents
  • 안소영 AHN, So Young
Priority Data
10-2016-017933426.12.2016KR
Publication Language Korean (KO)
Filing Language Korean (KO)
Designated States
Title
(EN) NOVEL PREPARATION CONTAINING BENZIMIDAZOLE DERIVATIVE
(FR) NOUVELLE PRÉPARATION CONTENANT UN DÉRIVÉ DE BENZIMIDAZOLE
(KO) 벤즈이미다졸 유도체를 포함하는 신규한 제제
Abstract
(EN)
The present invention relates to a novel preparation containing a benzimidazole derivative. According to the present invention, a preparation for oral administration, comprising: a compound of chemical formula 1 or a pharmaceutically acceptable salt thereof; and one or more disintegrating agents selected from the group consisting of croscarmellose sodium, sodium starch glycolate and a hydroxypropyl cellulose having a low degree of substitution, exhibits excellent storage stability and an effect of preventing deterioration of a dissolution rate, thereby being useful as a preparation for oral administration.
(FR)
La présente invention concerne une nouvelle préparation contenant un dérivé de benzimidazole. Selon la présente invention, une préparation pour administration orale, comprenant : un composé de formule chimique 1 ou un sel pharmaceutiquement acceptable de celui-ci ; et un ou plusieurs agents de désintégration choisis dans le groupe constitué de croscarmellose sodique, de glycolate d'amidon de sodium et d'une cellulose d'hydroxypropyle ayant un faible degré de substitution, présente une excellente stabilité au stockage et un effet de prévention de la détérioration d'un taux de dissolution, étant ainsi utile en tant que préparation pour une administration orale.
(KO)
본 발명은 벤즈이미다졸 유도체를 포함하는 신규한 제제에 관한 것이다. 본 발명에 따른 화학식 1의 화합물 또는 이의 약제학적으로 허용되는 염; 및 크로스카르멜로오스나트륨, 전분글리콜산나트륨 및 저치환도 히드록시프로필셀룰로오스로 구성된 군으로부터 선택되는 하나 이상의 붕해제를 포함하는 경구 투여용 제제는 우수한 저장 안정성과 용출률의 저하 현상을 방지하는 효과를 나타내어 경구투여용 제제로 유용하게 사용될 수 있다.
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