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1. (WO2018124696) NOVEL CAFFEIC ACID COMPOUND SEPARATED FROM STAUNTONIA HEXAPHYLLA LEAF EXTRACT, AND COMPOUND, FOR PROMOTING ANTI-INFLAMMATION, BONE FORMATION OR CARTILAGE FORMATION, HAVING SAME AS ACTIVE INGREDIENT
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Pub. No.: WO/2018/124696 International Application No.: PCT/KR2017/015480
Publication Date: 05.07.2018 International Filing Date: 26.12.2017
IPC:
C07H 15/203 (2006.01) ,A61K 31/7034 (2006.01) ,A61K 36/185 (2006.01) ,A23L 33/10 (2016.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
15
Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
20
Carbocyclic rings
203
Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7028
Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
7034
attached to a carbocyclic compound, e.g. phloridzin
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36
Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
18
Magnoliophyta (angiosperms)
185
Magnoliopsida (dicotyledons)
[IPC code unknown for A23L 33/10]
Applicants:
영진약품 주식회사 YUNGJIN PHARM. CO., LTD. [KR/KR]; 서울시 송파구 올림픽로35다길 13 13, Olympic-ro 35da-gil, Songpa-gu, Seoul 05510, KR
재단법인 전남생물산업진흥원 JEONNAM BIOINDUSTRY FOUNDATION [KR/KR]; 전라남도 나주시 동수농공단지길 30-5 30-5, Dongsunonggongdanji-gil Naju-si Jeollanam-do 58275, KR
Inventors:
이용남 LEE, Yongnam; KR
이동구 LEE, Dong Gu; KR
유지석 YOO, Ji-Seok; KR
최철웅 CHOI, Chulyung; KR
반상오 PAN, Sang O; KR
강후원 KANG, Hu Won; KR
김재용 KIM, Jae Yong; KR
이규옥 LEE, Gyu Ok; KR
김재갑 KIM, Jae Gap; KR
Agent:
유미 특허법인 YOU ME PATENT AND LAW FIRM; 서울시 강남구 테헤란로 115 115 Teheran-ro Gangnam-gu Seoul 06134, KR
Priority Data:
10-2016-018292429.12.2016KR
Title (EN) NOVEL CAFFEIC ACID COMPOUND SEPARATED FROM STAUNTONIA HEXAPHYLLA LEAF EXTRACT, AND COMPOUND, FOR PROMOTING ANTI-INFLAMMATION, BONE FORMATION OR CARTILAGE FORMATION, HAVING SAME AS ACTIVE INGREDIENT
(FR) NOUVEAU COMPOSÉ D'ACIDE CAFÉIQUE SÉPARÉ DE L'EXTRAIT DE FEUILLES DE STAUNTONIA HEXAPHYLLA, ET COMPOSÉ, POUR FAVORISER L'ANTI-INFLAMMATION, LA FORMATION OSSEUSE OU LA FORMATION DE CARTILAGE, AYANT CE COMPOSÉ COMME PRINCIPE ACTIF
(KO) 멀꿀 잎 추출물로부터 분리된 신규한 카페인산 화합물 및 이를 유효성분으로 하는 항염, 골조직 생성 또는 연골조직 생성 촉진용 조성물
Abstract:
(EN) The present invention relates to a novel caffeic acid compound separated from a Stauntonia hexaphylla leaf, and a pharmaceutical or food composition, for promoting bone formation or cartilage formation or for preventing, remedying or treating bone or cartilage destruction such as rheumatoid arthritis, having same as an active ingredient. More specifically, the present invention relates to a pharmaceutical or food composition comprising as an active ingredient a compound represented by chemical formula (1) having a bone or cartilage formation promoting effect or a bone or cartilage destruction preventing, remedying or treating effect by means of inhibiting osteoclast differentiation and promoting collagen type II and aggrecan expression and production.
(FR) La présente invention concerne un nouveau composé d'acide caféique extrait d'une feuille de Stauntonia hexaphylla, et une composition pharmaceutique ou alimentaire, pour favoriser la formation osseuse ou la formation de cartilage, ou pour prévenir, remédier ou traiter une destruction osseuse ou cartilagineuse telle que la polyarthrite rhumatoïde, ayant ce composé comme principe actif. Plus spécifiquement, la présente invention concerne une composition pharmaceutique ou alimentaire comprenant en tant que principe actif un composé représenté par la formule chimique (1) ayant un effet favorisant la formation osseuse ou cartilagineuse ou un effet de prévention, de correction ou de traitement de la destruction osseuse ou cartilagineuse au moyen de l'inhibition de la différenciation des ostéoclastes et de la promotion de l'expression et de la production du collagène de type II et de l'aggrécane.
(KO) 본 발명은 멀꿀 (Stauntoni a hexaphylla) 잎에서 분리한 신규 카페인산 화합물 및 이를 유효성분으로 하는 골조직 또는 연골조직 생성 촉진용, 또는 류마티스 관절염과 같은 골조직 또는 연골조직 파괴 질환에 대한 예방, 개선 또는 치료용 약학적 또는 식품 조성물에 관한 것으로서, 보다 상세하게는, 파골세포 분화억제와 콜라겐 타입 II, 아그레칸 발현 및 생산 촉진를 통해 골조직 또는 연골조직 생성 촉진, 또는 골조직 또는 연골조직 파괴 질환에 대한 예방, 개선 또는 치료효과를 갖는 상기 화학식 1의 화합물을 유효성분으로 포함하는 약학적 또는 식품 조성물에 관한 것이다.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Korean (KO)
Filing Language: Korean (KO)