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1. (WO2018124644) NOVEL METHOD FOR PREPARING THIENOPYRIMIDINE COMPOUND AND INTERMEDIATE

Pub. No.:    WO/2018/124644    International Application No.:    PCT/KR2017/015297
Publication Date: Fri Jul 06 01:59:59 CEST 2018 International Filing Date: Fri Dec 22 00:59:59 CET 2017
IPC: C07D 495/04
A61K 31/519
A61K 31/496
Applicants: HANMI PHARM. CO., LTD.
한미약품 주식회사
Inventors: KIM, Hee Cheol
김희철
HA, Tae Hee
하태희
SUH, Kwee Hyun
서귀현
Title: NOVEL METHOD FOR PREPARING THIENOPYRIMIDINE COMPOUND AND INTERMEDIATE
Abstract:
The present invention relates to a novel method for preparing a thienopyrimidine compound having activities of selectively inhibiting tyrosine kinase, particularly mutant epidermal growth factor receptor tyrosine kinase, and a novel intermediate used therefor. The present invention can industrially mass-produce, more simply and efficiently than the prior art, a compound of formula (1), which is useful as a therapeutic agent for non-small cell lung cancer induced by mutant epidermal growth factor receptor tyrosine kinase.