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1. (WO2018124642) COMPOSITION FOR DIFFERENTIATION OF DENTAL PULP STEM CELLS INTO ODONTOBLAST PROGENITOR CELLS AND IGG OR IGM TYPE MONOCLONAL ANTIBODY SPECIFICALLY BINDING TO SURFACE OF ODONTOBLAST PROGENITOR CELLS

Pub. No.:    WO/2018/124642    International Application No.:    PCT/KR2017/015269
Publication Date: Fri Jul 06 01:59:59 CEST 2018 International Filing Date: Fri Dec 22 00:59:59 CET 2017
IPC: C07K 16/28
C12N 5/12
C12N 5/077
G01N 33/569
Applicants: DANKOOK UNIVERSITY CHEONAN CAMPUS INDUSTRY ACADEMIC COOPERATION FOUNDATION
단국대학교 천안캠퍼스 산학협력단
Inventors: JANG, Young Joo
장영주
KANG, Kyung Jung
강경정
Title: COMPOSITION FOR DIFFERENTIATION OF DENTAL PULP STEM CELLS INTO ODONTOBLAST PROGENITOR CELLS AND IGG OR IGM TYPE MONOCLONAL ANTIBODY SPECIFICALLY BINDING TO SURFACE OF ODONTOBLAST PROGENITOR CELLS
Abstract:
The present invention relates to a composition for differentiation of dental pulp stem cells into odontoblast progenitor cells and an IgG or IgM type monoclonal antibody specifically binding to the surface of the odontoblast progenitor cells differentiated from the dental pulp stem cells. According to the present invention, when BMP2 and BMP4 are treated in combination at an optimal ratio, the differentiation efficiency of the dental pulp stem cells into the odontoblast progenitor cells is significantly increased, the calcification of a matrix is induced, and the ability of the odontoblast progenitor cells to be differentiated into dentin is enhanced. In addition, when an IgG or IgM monoclonal antibody that specifically binds to the surface of the odontoblast progenitor cells of the present invention is employed, the odontoblast progenitor cells that can be usefully used for tissue regeneration and differentiation can be effectively isolated and purified.