Search International and National Patent Collections

1. (WO2018124512) APTAMER-DRUG CONJUGATE AND USE THEREOF

Pub. No.:    WO/2018/124512    International Application No.:    PCT/KR2017/014060
Publication Date: Fri Jul 06 01:59:59 CEST 2018 International Filing Date: Tue Dec 05 00:59:59 CET 2017
IPC: A61K 47/54
A61K 47/06
C12N 15/115
A61K 31/40
Applicants: LEE, Jung Hwan
이중환
INTEROLIGO CORPORATION
인터올리고 주식회사
Inventors: LEE, Jung Hwan
이중환
IM, Jong Hun
임종훈
KIM, Jong In
김종인
Title: APTAMER-DRUG CONJUGATE AND USE THEREOF
Abstract:
The present invention relates to a cancer targeted therapeutic comprising a drug-linker-AS1411 structure, wherein the drug may be selected from monomethyl auristatin E (MMAE), monomethyl auristatin F (MMAF), cytarabine, gemcitabine, maytansine, DM1, DM4, calicheamicin and a derivative thereof, doxorubicin, duocarmycin and a derivative thereof, pyrrolobenzodiazepine (PBD), SN-38, a-amanitin, and a tubulysin analog.