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1. (WO2018124508) COMPOSITION FOR PREVENTION AND TREATMENT OF MUSCULAR DISEASES OR FOR IMPROVEMENT OF MUSCLE FUNCTION CONTAINING 3,5-DICAFFEOYLQUINIC ACID OR CHRYSANTHEMUM EXTRACT
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Pub. No.: WO/2018/124508 International Application No.: PCT/KR2017/013879
Publication Date: 05.07.2018 International Filing Date: 30.11.2017
IPC:
A23L 33/10 (2016.01) ,A61K 36/287 (2006.01)
[IPC code unknown for A23L 33/10]
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36
Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
18
Magnoliophyta (angiosperms)
185
Magnoliopsida (dicotyledons)
28
Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
287
Chrysanthemum, e.g. daisy
Applicants:
연세대학교 산학협력단 INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY [KR/KR]; 서울시 서대문구 연세로 50 (신촌동, 연세대학교) (Yonsei University, Sinchon-dong) 50, Yonsei-ro, Seodaemun-gu, Seoul 03722, KR
(주) 뉴트리바이오텍 NUTRIBIOTECH [KR/KR]; 서울시 강남구 테헤란로 145, 1001호 (역삼동, 우신빌딩) (Wooshin Building, Yeoksam-dong) #1001, 145, Teheran-ro, Gangnam-gu, Seoul 06132, KR
Inventors:
황재관 HWANG, Jae Kwan; KR
윤준곤 YUN, Jun Gon; KR
김미보 KIM, Mi Bo; KR
김창희 KIM, Chang Hee; KR
이준형 LEE, Joon Hyung; KR
권진혁 KWON, Jin Hyouk; KR
윤만석 YOON, Mann Seok; KR
이진우 LEE, Jin Woo; KR
임재연 LIM, Jae Youn; KR
고동현 KO, Dong Hyeon; KR
권도완 KWON, Do Wan; KR
Agent:
특허법인 이룸리온 ERUUM & LEEON INTELLECTUAL PROPERTY LAW FIRM; 서울시 서초구 사평대로 108, 3층 (반포동) (Banpo-dong) 3rd Floor, 108, Sapyeong-daero, Seocho-gu, Seoul 06575, KR
Priority Data:
10-2016-018364930.12.2016KR
Title (EN) COMPOSITION FOR PREVENTION AND TREATMENT OF MUSCULAR DISEASES OR FOR IMPROVEMENT OF MUSCLE FUNCTION CONTAINING 3,5-DICAFFEOYLQUINIC ACID OR CHRYSANTHEMUM EXTRACT
(FR) COMPOSITION POUR LA PRÉVENTION ET LE TRAITEMENT DE MALADIES MUSCULAIRES OU POUR L'AMÉLIORATION DE LA FONCTION MUSCULAIRE, CONTENANT DE L'ACIDE 3,5-DICAFÉOYLQUINIQUE OU DE L'EXTRAIT DE CHRYSANTHÈME
(KO) 3,5-디카페오일퀴닉에시드 또는 국화 추출물을 함유하는 근육 질환 예방 및 치료용 또는 근 기능 개선용 조성물
Abstract:
(EN) The present invention relates to a composition for preventing or treating muscular diseases, which contains an extract of chrysanthemum and 3,5-dicaffeoylquinic acid as active ingredients. Specifically, since the present invention reduces mRNA expression of atrogin-1 and MuRF-1, which are major biomarkers involved in muscle protein degradation in muscle cells, and reduces muscle loss by increasing mRNA expression of mTOR protein, which is a major biomarker involved in muscle protein formation, and myogenin and MyoD, which are biomarkers associated with muscle differentiation, the present invention can be used for preventing and treating muscular diseases or improving muscle function. In addition, the chrysanthemum extract or the 3,5-dicaffeoylquinic acid has an effect of excellently improving exercise performance by increasing the activity of SIRT1 and PCG-1α which are major biomarkers involved in exercise performance. Moreover, since the present invention is a natural product, the present invention can be safely used without side effects and can be used as medicine, food, or cosmetics.
(FR) La présente invention concerne une composition pour la prévention ou le traitement de maladies musculaires, qui contient un extrait de chrysanthème et de l'acide 3,5-dicaféoylquinique en tant que principes actifs. Spécifiquement, étant donné que la présente invention réduit l'expression d'ARNm de l'atrogine-1 et de la MuRF-1, qui sont des biomarqueurs majeurs impliqués dans la dégradation des protéines musculaires dans les cellules musculaires, et réduit la perte musculaire par l'augmentation de l'expression d'ARNm de la protéine mTOR, qui est un biomarqueur majeur impliqué dans la formation de protéine musculaire, et de la myogénine et la MyoD, qui sont des biomarqueurs associés à la différenciation musculaire, la présente invention peut être utilisée pour prévenir et traiter des maladies musculaires ou améliorer la fonction musculaire. De plus, l'extrait de chrysanthème ou l'acide 3,5-dicaféoylquinique a pour effet d'améliorer remarquablement les performances d'exercice en augmentant l'activité de la SIRT1 et du PCG-1α, qui sont des biomarqueurs majeurs impliqués dans les performances d'exercice. En outre, la présente invention est un produit naturel et ainsi peut être utilisée en toute sécurité, sans effets secondaires, et peut être utilisée comme médicament, aliment, ou produit cosmétique.
(KO) 본 발명은 국화 추출물 및 3,5-디카페오일퀴닉에시드(3,5-dicaffeoylquinic acid)를 유효성분으로 함유하는 근육 질환 예방 또는 치료용 조성물에 관한 것으로, 구체적으로, 근육세포에서 근 단백질 분해에 관여하는 주요 생체지표인 atrogin-1과 MuRF-1의 mRNA 발현을 감소시키고, 근 단백질 형성에 관여하는 주요 생체지표인 mTOR 단백질과, 근육 분화 관련 생체지표인 myogenin과 MyoD의 mRNA 발현을 증가시킴으로써 근 손실을 감소시킬 수 있는 바, 근육 질환의 예방, 치료 또는 근 기능 개선에 이용될 수 있다. 또한, 상기 국화 추출물 또는 3,5-디카페오일퀴닉에시드는 운동수행능력에 관여하는 주요 생체지표인 SIRT1및 PCG-1α의 활성을 증가시킴으로써, 운동수행능력을 탁월하게 향상시키는 효과가 있다. 또한, 본 발명은 천연물이므로 부작용 없이 안전하게 사용될 수 있어, 의약품, 식품 또는 화장품으로 사용될 수 있다.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Korean (KO)
Filing Language: Korean (KO)