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1. (WO2018124440) NOVEL ISOPROPYLMALATE SYNTHASE MUTANT AND PRODUCTION METHOD OF L-LEUCINE USING SAME
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Pub. No.: WO/2018/124440 International Application No.: PCT/KR2017/011622
Publication Date: 05.07.2018 International Filing Date: 20.10.2017
IPC:
C12N 9/10 (2006.01) ,C12N 15/52 (2006.01) ,C12N 15/77 (2006.01) ,C12P 13/06 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9
Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
10
Transferases (2.)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
52
Genes encoding for enzymes or proenzymes
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
74
Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
77
for Corynebacterium; for Brevibacterium
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
13
Preparation of nitrogen-containing organic compounds
04
Alpha- or beta-amino acids
06
Alanine; Leucine; Isoleucine; Serine; Homoserine
Applicants:
씨제이제일제당 (주) CJ CHEILJEDANG CORPORATION [KR/KR]; 서울시 중구 동호로 330 330, Dongho-ro, Jung-gu, Seoul 04560, KR
Inventors:
이지혜 LEE, Ji Hye; KR
송병철 SONG, Byeong Cheol; KR
전애지 JEON, Ae Ji; KR
김종현 KIM, Jong Hyun; KR
김혜원 KIM, Hye Won; KR
Agent:
손민 SON, Min; KR
Priority Data:
10-2016-018134328.12.2016KR
Title (EN) NOVEL ISOPROPYLMALATE SYNTHASE MUTANT AND PRODUCTION METHOD OF L-LEUCINE USING SAME
(FR) NOUVEAU MUTANT DE L'ISOPROPYLMALATE SYNTHASE ET PROCÉDÉ DE PRODUCTION DE L-LEUCINE FAISANT APPEL À CELUI-CI
(KO) 신규한 이소프로필말레이트 신타제 변이체 및 이를 이용한 L-류신의 생산 방법
Abstract:
(EN) The present application relates to novel mutant polypeptide having isopropylmalate synthase activity, a polynucleotide coding for the same, a microorganism including the polypeptide, and a method for producing L-leucine by culturing the microorganism.
(FR) La présente invention concerne un nouveau polypeptide mutant possédant une activité isopropylmalate synthase, un polynucléotide codant pour celui-ci, un microorganisme comprenant ce polypeptide et un procédé de production de L-leucine par culture du microorganisme.
(KO) 본 출원은 이소프로필말레이트 신타제 (isopropylmalate synthase) 활성을 가지는 신규 변이형 폴리펩티드, 이를 코딩하는 폴리뉴클레오티드, 상기 폴리펩티드를 포함하는 미생물, 및 상기 미생물을 배양하여 L-류신을 생산하는 방법에 관한 것이다.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Korean (KO)
Filing Language: Korean (KO)