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1. (WO2018124393) VACCINE COMPOSITION FOR PREVENTING OR TREATING BRUCELLOSIS CONTAINING NON-PATHOGENIC SALMONELLA STRAIN IN WHICH O-ANTIGEN OF LPS IS DELETED EXPRESSING MAJOR COMMON ANTIGENS OF BRUCELLA
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Pub. No.: WO/2018/124393 International Application No.: PCT/KR2017/002866
Publication Date: 05.07.2018 International Filing Date: 17.03.2017
IPC:
A61K 39/112 (2006.01) ,A61K 39/02 (2006.01) ,A23K 10/16 (2016.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
02
Bacterial antigens
112
Salmonella; Shigella
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
02
Bacterial antigens
[IPC code unknown for A23K 10/16]
Applicants:
전북대학교산학협력단 INDUSTRIAL COOPERATION FOUNDATION CHONBUK NATIONAL UNIVERSITY [KR/KR]; 전라북도 전주시 덕진구 백제대로 567 567, Baekje-daero Deokjin-gu, Jeonju-si Jeollabuk-do 54896, KR
Inventors:
이존화 LEE, John Hwa; KR
넬시암다라조나탄 LALSIAMTHARA, Jonathan; KR
원가연 WON, Ga Yeon; KR
허진 HUR, Jin; KR
Agent:
최규환 CHOI, Kyu Whan; KR
Priority Data:
10-2016-017894326.12.2016KR
Title (EN) VACCINE COMPOSITION FOR PREVENTING OR TREATING BRUCELLOSIS CONTAINING NON-PATHOGENIC SALMONELLA STRAIN IN WHICH O-ANTIGEN OF LPS IS DELETED EXPRESSING MAJOR COMMON ANTIGENS OF BRUCELLA
(FR) COMPOSITION VACCINALE POUR LA PRÉVENTION OU LE TRAITEMENT DE LA BRUCELLOSE CONTENANT UNE SOUCHE DE SALMONELLE NON PATHOGÈNE DANS LAQUELLE UN ANTIGÈNE O DE LPS EST SUPPRIMÉ, EXPRIMANT DES ANTIGÈNES COMMUNS MAJEURS BRUCELLIQUES
(KO) 브루셀라 균 주요 공통 항원을 발현하는 LPS의 O-항원 결실 비병원성 살모넬라 균주를 포함하는 브루셀라증 예방 또는 치료용 백신 조성물
Abstract:
(EN) The present invention relates to a vaccine composition for preventing brucellosis using a non-pathogenic Salmonella strain in which the O-antigen in an LPS is deleted, which expresses major common antigens of Brucella. When attenuated Salmonella in which the O-antigen of LPS is deleted was transformed using a vector developed to increase secretion of Brucella abortus-derived BLS, Omp19, PrpA and SOD antigens, and a mouse was vaccinated with a mixture of the Salmonella mutant that has been transformed and challenge infected, the present invention was confirmed to effectively induce humoral and cell-mediated immune responses to antigens in the mouse and provide an excellent defensive effect. As a result, the mutant according to the present invention is expected to be useful as a preventative or a therapeutic vaccine for brucella or Salmonella which is safe, economical, and safely inoculated.
(FR) La présente invention concerne une composition vaccinale pour prévenir la brucellose à l'aide d'une souche de salmonelle non pathogène dans laquelle l'antigène O dans un LPS est supprimé, qui exprime des antigènes communs majeurs brucelliques. Lorsqu'une salmonelle atténuée dans laquelle l'antigène O du LPS est supprimé a été transformée à l'aide d'un vecteur développé pour augmenter la sécrétion des antigènes BLS, Omp19, PrpA et SOD dérivés de Brucella abortus, et une souris a été vaccinée avec un mélange du mutant de salmonelle qui a été transformé et infecté par simulation, il a été démontré que la présente invention permettait d'induire efficacement des réponses immunitaires humorales et médiées par les cellules à des antigènes dans la souris et fournissait un excellent effet défensif. Par conséquent, le mutant selon la présente invention est censé être utile en tant que vaccin préventif ou thérapeutique pour la brucelle ou la salmonelle, qui est sûr, économique, et inoculé en toute sécurité.
(KO) 본 발명은 브루셀라 균 주요 공통 항원을 발현하는 LPS의 O-항원 결실 비병원성 살모넬라 균주을 이용한 브루셀라증 예방용 백신 조성물에 관한 것이다. 본 발명은 브루셀라 아보투스(Brucella abortus) 유래 BLS, Omp19, PrpA 및 SOD 항원의 분비를 증가시키도록 개발된 벡터로 LPS의 O-항원이 결실된 약독화 살모넬라균을 형질전환시키고 상기 형질전환된 살모넬라 변이주의 혼합물을 접종시킨 마우스에서 항원에 대한 체액성 및 세포성 면역 반응 유도 및 도전 감염시 방어 효과가 우수함을 확인하였다. 따라서, 본 발명의 변이주는 안전하고 경제적이며 간편하게 접종할 수 있는 브루셀라증 및 살모넬라증 예방 또는 치료용 백신으로 유용하게 사용될 것으로 기대된다.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Korean (KO)
Filing Language: Korean (KO)