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1. (WO2018124283) PHARMACEUTICAL COMPOSITION

Pub. No.:    WO/2018/124283    International Application No.:    PCT/JP2017/047253
Publication Date: Fri Jul 06 01:59:59 CEST 2018 International Filing Date: Fri Dec 29 00:59:59 CET 2017
IPC: A61K 31/397
A61K 9/16
A61K 9/20
A61K 47/12
A61K 47/18
A61K 47/32
A61P 25/00
A61P 43/00
Applicants: TOYAMA CHEMICAL CO., LTD.
富山化学工業株式会社
Inventors: OKADA Kotaro
岡田 康太郎
SAKATA Yoshinori
阪田 佳紀
TSUJIHATA Shigetomo
辻畑 茂朝
Title: PHARMACEUTICAL COMPOSITION
Abstract:
The present invention addresses the problem of providing a solid pharmaceutical composition that suppresses the bitter taste characteristic of 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or a salt thereof and has excellent storage stability of the compound or salt thereof. The present invention provides a solid pharmaceutical composition including 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or a salt thereof, and a carboxylic acid having a solubility of 50 g/100 g H2O or lower in 25°C water, wherein when 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or a salt thereof is dissolved or suspended in 10 mmol/L KCl solution so as to reach 1 mg/mL or 8.96 mg/mL, the pH of the solution is 4.8 or lower.