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1. (WO2018124282) PHARMACEUTICAL COMPOSITION AND METHOD FOR PRODUCING SAME

Pub. No.:    WO/2018/124282    International Application No.:    PCT/JP2017/047252
Publication Date: Fri Jul 06 01:59:59 CEST 2018 International Filing Date: Fri Dec 29 00:59:59 CET 2017
IPC: A61K 31/397
A61K 9/16
A61K 9/32
A61K 47/32
A61K 47/34
A61K 47/36
A61K 47/38
A61P 25/00
A61P 43/00
Applicants: TOYAMA CHEMICAL CO., LTD.
富山化学工業株式会社
Inventors: OKADA Kotaro
岡田 康太郎
SAKATA Yoshinori
阪田 佳紀
TSUJIHATA Shigetomo
辻畑 茂朝
Title: PHARMACEUTICAL COMPOSITION AND METHOD FOR PRODUCING SAME
Abstract:
The present invention addresses the problem of providing a pharmaceutical composition that contains a high concentration of 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or a salt thereof and masks the bitter taste thereof, and a method for producing the pharmaceutical composition. The present invention provides a pharmaceutical composition containing granules that have a core including 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or a salt thereof and a binder, and have a polymer layer coated on the surface of the core, the granules having a roundness of 0.8 or higher, and the amount of 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or salt thereof contained in the granules being 30-90% by mass.