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1. (WO2018124236) MEDICINAL COMPOSITION FOR TREATING INTRACTABLE HEART DISEASE

Pub. No.:    WO/2018/124236    International Application No.:    PCT/JP2017/047100
Publication Date: Fri Jul 06 01:59:59 CEST 2018 International Filing Date: Thu Dec 28 00:59:59 CET 2017
IPC: A61K 45/06
A61K 9/14
A61K 9/50
A61K 9/70
A61K 31/24
A61K 31/366
A61K 31/4174
A61K 31/4418
A61K 31/4709
A61K 31/496
A61K 31/519
A61K 31/522
A61L 15/40
A61L 15/64
A61P 9/00
A61P 9/04
A61P 9/06
A61P 9/10
A61P 43/00
C07D 209/34
C07D 213/64
C07D 233/60
C07D 309/30
C07D 401/12
C07D 473/08
C07D 487/04
Applicants: OSAKA UNIVERSITY
国立大学法人大阪大学
CARDIO INCORPORATED
株式会社カルディオ
Inventors: SAWA, Yoshiki
澤 芳樹
MIYAGAWA, Shigeru
宮川 繁
SAKAI, Yoshiki
酒井 芳紀
YANAGI, Yasuhiro
柳 裕啓
Title: MEDICINAL COMPOSITION FOR TREATING INTRACTABLE HEART DISEASE
Abstract:
Provided is a medicinal composition to be used for treating an intractable heart tissue fibrosis disease accompanying chronic heart failure. The medicinal composition, which is to be used for treating an intractable heart tissue fibrosis disease accompanying chronic heart failure, comprises as an active ingredient at least one member selected from the group consisting of a protease inhibitor, a thromboxane A2 synthase inhibitor and an antagonist thereof, a phosphodiesterase (PDE) inhibitor, a tyrosine kinase inhibitor, an HMG-CoA reductase inhibitor and an anti-fibrosis agent. (Said medicinal composition includes a sustainable preparation thereof enclosed in a biodegradable polymer.)