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1. (WO2018124180) ANTITUMOR AGENT AND BROMODOMAIN INHIBITOR

Pub. No.:    WO/2018/124180    International Application No.:    PCT/JP2017/046901
Publication Date: Fri Jul 06 01:59:59 CEST 2018 International Filing Date: Thu Dec 28 00:59:59 CET 2017
IPC: A61K 31/4704
A61K 31/4709
A61K 31/4725
A61K 31/497
A61K 31/5377
A61P 35/00
A61P 35/02
A61P 43/00
Applicants: FUJIFILM CORPORATION
富士フイルム株式会社
TOYAMA CHEMICAL CO., LTD.
富山化学工業株式会社
NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY
国立研究開発法人産業技術総合研究所
Inventors: MAKITA Keiko
牧田 慶子
SAEKI Kazunori
佐伯 和徳
TANAKA Tadashi
田中 正
FUJINO Masataka
藤野 正堂
NATSUME Tohru
夏目 徹
FURUYA Kentaro
古屋 賢太朗
Title: ANTITUMOR AGENT AND BROMODOMAIN INHIBITOR
Abstract:
The present invention addresses the problem of providing an antitumor agent that is exceptional as a treatment agent for the prevention and/or treatment of tumors involving bromodomains, and providing a bromodomain inhibitor that is useful as a treatment agent for diseases or conditions involving bromodomains. An antitumor agent and bromodomain inhibitor containing a compound represented by the general formula [in the formula, R1 represents a C1-6 alkyl group, etc.; R2 represents a hydrogen atom, etc.; R3 represents a halogen atom, etc.; Z1, Z2, and Z3 represent CH, etc.; X1 represents CONH, etc.; ring A represents a phenyl group, etc.; R4 represents a halogen atom, etc.; and m represents an integer of 0-5] have exceptional bromodomain inhibitory activity and are useful as treatment agents for the prevention and/or treatment of tumors involving bromodomains.