Search International and National Patent Collections

1. (WO2018124162) SELF-EMULSIFYING DRUG FORMULATION FOR IMPROVING MEMBRANE PERMEABILITY OF COMPOUND

Pub. No.:    WO/2018/124162    International Application No.:    PCT/JP2017/046844
Publication Date: Fri Jul 06 01:59:59 CEST 2018 International Filing Date: Thu Dec 28 00:59:59 CET 2017
IPC: A61K 9/107
A61K 47/10
A61K 47/14
A61K 47/44
Applicants: CHUGAI SEIYAKU KABUSHIKI KAISHA
中外製薬株式会社
Inventors: TAMPO, Yoshihiro
反保 佳弘
TAKANO, Ryusuke
▲高▼野 隆介
HISADA, Nozomi
久田 望
SAKAI, Kenichi
酒井 憲一
OZEKI, Kazuhisa
尾関 和久
SAKURAI, Yuji
櫻井 裕治
HIGASHIDA, Atsuko
東田 敦子
Title: SELF-EMULSIFYING DRUG FORMULATION FOR IMPROVING MEMBRANE PERMEABILITY OF COMPOUND
Abstract:
The present invention addresses the problem of providing a lymphatically-transported self-emulsifying drug formulation with a view to promoting membrane permeability in oral administration of a poorly membrane-permeable compound. It has been discovered that by applying a lymphatically-transported self-emulsifying drug formulation comprising an oily component or surfactant containing oleic acid as a partial structure to a poorly membrane-permeable compound containing a cyclic peptide having characteristics (i) and (ii) indicated below, the membrane permeability and absorption property of said compound can be improved: (i) the compound has a logD (pH 7.4) value of not less than 3.2; and (ii) the compound has a Caco-2 Papp (cm/sec) value of not greater than 1.8E-6.