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|1. (WO2018124162) SELF-EMULSIFYING DRUG FORMULATION FOR IMPROVING MEMBRANE PERMEABILITY OF COMPOUND|
|Applicants:||CHUGAI SEIYAKU KABUSHIKI KAISHA
|Title:||SELF-EMULSIFYING DRUG FORMULATION FOR IMPROVING MEMBRANE PERMEABILITY OF COMPOUND|
The present invention addresses the problem of providing a lymphatically-transported self-emulsifying drug formulation with a view to promoting membrane permeability in oral administration of a poorly membrane-permeable compound. It has been discovered that by applying a lymphatically-transported self-emulsifying drug formulation comprising an oily component or surfactant containing oleic acid as a partial structure to a poorly membrane-permeable compound containing a cyclic peptide having characteristics (i) and (ii) indicated below, the membrane permeability and absorption property of said compound can be improved: (i) the compound has a logD (pH 7.4) value of not less than 3.2; and (ii) the compound has a Caco-2 Papp (cm/sec) value of not greater than 1.8E-6.