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1. (WO2018124132) OIL-IN-WATER EMULSION PREPARATION CONTAINING BACTERIAL CELL WALL SKELETON COMPONENT

Pub. No.:    WO/2018/124132    International Application No.:    PCT/JP2017/046780
Publication Date: Fri Jul 06 01:59:59 CEST 2018 International Filing Date: Wed Dec 27 00:59:59 CET 2017
IPC: A61K 35/74
A61K 39/00
A61K 39/39
A61P 35/00
A61P 37/04
C12N 1/20
Applicants: JAPAN BCG LABORATORY
日本ビーシージー製造株式会社
Inventors: NAKAYA, Akihiro
中谷 彰洋
SHIBUYA, Yukihiro
渋谷 幸広
CHUMA, Yasushi
中馬 康志
SUNAGAWA, Makoto
砂川 洵
SATO, Yoshimoto
佐藤 仁尤
Title: OIL-IN-WATER EMULSION PREPARATION CONTAINING BACTERIAL CELL WALL SKELETON COMPONENT
Abstract:
Bacterial CWS having a mycolic acid moiety and some arabinogalactan exposed on the surface was prepared, whereby when the prepared bacterial CWS was used to prepare an oil-in-water emulsion, it was possible to prepare a novel oil-in-water emulsion having the arabinogalactan of the bacterial CWS protruding and exposed on the surface of oil particles and a lyophilized preparation of the oil-in-water emulsion. This emulsion preparation exhibits superior immunostimulatory activity together with exceptional stability. As a result, new immunotherapeutic agents for cancer could be prepared using this emulsion preparation.