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1. (WO2018124060) NOVEL COMPOUND AND PHARMACEUTICALLY-ACCEPTABLE SALT THEREOF

Pub. No.:    WO/2018/124060    International Application No.:    PCT/JP2017/046610
Publication Date: Fri Jul 06 01:59:59 CEST 2018 International Filing Date: Wed Dec 27 00:59:59 CET 2017
IPC: C07D 471/08
A61K 31/4995
A61K 31/501
A61K 31/506
A61K 31/5377
A61K 31/5386
A61K 31/541
A61K 31/55
A61P 11/06
A61P 17/06
A61P 25/24
A61P 25/28
A61P 35/00
C07D 487/08
C07D 498/08
Applicants: MEIJI SEIKA PHARMA CO., LTD.
Meiji Seikaファルマ株式会社
Inventors: TAMURA Keiji
田村 圭司
YAMAKAWA Takeru
山川 建
ISSHIKI Satoshi
一色 聡志
WAKIYAMA Yoshinari
脇山 佳也
OUCHI Shohei
大内 祥平
MATSUHIRA Takashi
松平 崇
ISHIDA Natsuki
石田 那月
TABATA Yuji
田端 祐二
Title: NOVEL COMPOUND AND PHARMACEUTICALLY-ACCEPTABLE SALT THEREOF
Abstract:
Provided is a compound represented by general formula (1) or a pharmaceutically-acceptable salt thereof. [In formula (1), R1 and R2 may be the same or different from each other, and each represents a hydrogen atom, a halogen atom, a hydroxy group, a carboxy group, a cyano group, or an optionally-substituted C1-6 alkyl group or the like; R3 represents a hydrogen atom; R4 represents an optionally-substituted 4- to 10-membered monocyclic heterocyclic group containing 1-4 heteroatoms selected from an oxygen atom, a nitrogen atom, and a sulfur atom; X represents a group represented by -CH2-, -CH2-CH2-, -CH2-CH2-CH2-, or -CH2-O-CH2-; and Z represents a hydrogen atom or a hydroxy group.]