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1. (WO2018123999) METHOD FOR SELECTING INDIVIDUALS TO BE ADMINISTERED IMMUNE CHECKPOINT INHIBITOR

Pub. No.:    WO/2018/123999    International Application No.:    PCT/JP2017/046503
Publication Date: Fri Jul 06 01:59:59 CEST 2018 International Filing Date: Tue Dec 26 00:59:59 CET 2017
IPC: G01N 33/68
A61K 39/395
A61K 45/00
A61P 35/00
G01N 33/48
G01N 33/53
Applicants: KINKI UNIVERSITY
学校法人近畿大学
DAIICHI SANKYO COMPANY, LIMITED
第一三共株式会社
Inventors: YONESAKA Kimio
米阪 仁雄
NAKAGAWA Kazuhiko
中川 和彦
HIROTANI Kenji
廣谷 賢志
Title: METHOD FOR SELECTING INDIVIDUALS TO BE ADMINISTERED IMMUNE CHECKPOINT INHIBITOR
Abstract:
[Problem] To provide a method for selecting individuals for whom administration of an immune checkpoint inhibitor would be effective, by extracting tumor tissue from individuals who have developed tumors and determining the level of expression of B7-H3 in the extracted tumor tissue. [Solution] A method for selecting individuals to be administered an immune checkpoint inhibitor when treating a tumor, said selection method characterized by comprising: (1) a step for extracting tumor tissue from said individuals; (2) a step for determining the degree of expression of B7-H3 in the tumor tissue extracted at (1); and (3) a step for selecting, as subjects to be administered an immune checkpoint inhibitor, individuals for whom it has been determined that the level of expression of B7-H3 is negative.