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1. (WO2018123945) DEPOT PREPARATION COMPRISING TAFLUPROST AND CITRIC ACID ESTER

Pub. No.:    WO/2018/123945    International Application No.:    PCT/JP2017/046379
Publication Date: Fri Jul 06 01:59:59 CEST 2018 International Filing Date: Tue Dec 26 00:59:59 CET 2017
IPC: A61K 31/5575
A61K 9/08
A61K 9/10
A61K 47/14
A61P 27/02
A61P 27/06
Applicants: SANTEN PHARMACEUTICAL CO., LTD.
参天製薬株式会社
AGC INC.
AGC株式会社
Inventors: MIYAZAKI Tatsuya
宮崎 達也
MASAKI Kenji
眞崎 賢治
TAKAHASHI Kyohei
▲高▼橋 恭平
YAMADA Kazuhito
山田 和人
Title: DEPOT PREPARATION COMPRISING TAFLUPROST AND CITRIC ACID ESTER
Abstract:
Provided are: a depot preparation comprising tafluprost which can form depots easily and can maintain the depot-formed state for a long period so that tafluprost can be sustainably released over a long period of time after in vivo administration thereof; and a method for stabilizing tafluprost. The present invention pertains to a depot preparation comprising tafluprost and a trialkyl citrate and/or an acetyltrialkyl citrate, wherein the alkyl groups in the trialkyl citrate and the alkyl groups in the acetyltrialkyl citrate are either the same or different and each of these alkyl groups has 3-5 carbon atoms.