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1. (WO2018123627) CELL PHARMACEUTICAL COMPOSITION, DISEASE TREATMENT KIT, AND CELL SUSPENSION SOLUTION
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Pub. No.: WO/2018/123627 International Application No.: PCT/JP2017/044992
Publication Date: 05.07.2018 International Filing Date: 14.12.2017
IPC:
A61K 35/12 (2015.01) ,A61K 9/10 (2006.01) ,A61K 35/14 (2015.01) ,A61K 35/28 (2015.01) ,A61K 35/35 (2015.01) ,A61K 35/51 (2015.01) ,A61K 47/02 (2006.01) ,A61K 47/12 (2006.01) ,A61K 47/26 (2006.01) ,C12N 5/0775 (2010.01) ,C12N 5/078 (2010.01)
Applicants: ROHTO PHARMACEUTICAL CO., LTD.[JP/JP]; 1-8-1, Tatsumi-nishi, Ikuno-ku, Osaka-shi, Osaka 5448666, JP
Inventors: TAKEDA Rie; JP
NAGAOKA Kumiko; JP
HORIUCHI Youko; JP
HASEGAWA Hikari; JP
TAMADA Kotoe; JP
Agent: TSUKUNI & ASSOCIATES; Kojimachi Business Center, 5-3-1, Kojimachi, Chiyoda-ku, Tokyo 1020083, JP
YAMAMURA Daisuke; JP
MORITA Yoshiko; JP
Priority Data:
2016-25663228.12.2016JP
Title (EN) CELL PHARMACEUTICAL COMPOSITION, DISEASE TREATMENT KIT, AND CELL SUSPENSION SOLUTION
(FR) COMPOSITION PHARMACEUTIQUE DE CELLULES, KIT POUR TRAITEMENT DE MALADIE, ET SOLUTION POUR SUSPENSION DE CELLULES
(JA) 細胞医薬組成物、疾患治療用キット及び細胞懸濁用溶液
Abstract:
(EN) The present invention addresses the issue of providing a cell pharmaceutical composition capable of maintaining a cell state well and a high survival rate over the long term. This cell pharmaceutical composition contains cells (A) and a cell suspension solution (B) including electrolytes and carbohydrates. The electrolytes in the cell suspension solution (B) include Na+ and Cl and do not substantially include K+. Ideally, the electrolytes in the cell suspension solution (B) would also be substantially only Na+ and Cl or substantially only Na+, Cl, and Lac.
(FR) L’invention a pour objet de fournir une composition pharmaceutique de cellules qui préserve de manière satisfaisante l’état de cellules, et qui permet de maintenir un taux de survie élevé sur une longue durée. Plus précisément, l’invention concerne une composition pharmaceutique de cellules qui comprend des cellules (A), et une solution pour suspension de cellules (B) contenant un électrolyte et un glucide. Ledit électrolyte de la solution pour suspension de cellules (B), contient Na et Cl, mais ne contient pas de manière pratique de K. En outre, de préférence, ledit électrolyte de la solution pour suspension de cellules (B), de manière pratique consiste en Na et Cl uniquement, ou en Na, Cl et uniquement.
(JA) 本発明は、細胞の状態を良好に保ち、生存率を長時間に渡って高く維持することができる細胞医薬組成物を提供することを課題とする。 本発明は、(A)細胞、並びに(B)電解質及び糖質を含む細胞懸濁用溶液を含有し、(B)細胞懸濁用溶液における上記電解質が、Na及びClを含み、Kを実質的に含まない、細胞医薬組成物である。(B)細胞懸濁用溶液における上記電解質はまた、実質的にNa及びClのみ、又は実質的にNa、Cl及びLacのみであることが好ましい。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)