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1. (WO2018123627) CELL PHARMACEUTICAL COMPOSITION, DISEASE TREATMENT KIT, AND CELL SUSPENSION SOLUTION
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Pub. No.: WO/2018/123627 International Application No.: PCT/JP2017/044992
Publication Date: 05.07.2018 International Filing Date: 14.12.2017
IPC:
A61K 35/12 (2015.01) ,A61K 9/10 (2006.01) ,A61K 35/14 (2015.01) ,A61K 35/28 (2015.01) ,A61K 35/35 (2015.01) ,A61K 35/51 (2015.01) ,A61K 47/02 (2006.01) ,A61K 47/12 (2006.01) ,A61K 47/26 (2006.01) ,C12N 5/0775 (2010.01) ,C12N 5/078 (2010.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
12
Materials from mammals or birds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
10
Dispersions; Emulsions
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
12
Materials from mammals or birds
14
Blood
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
12
Materials from mammals or birds
28
Marrow; Spleen
[IPC code unknown for A61K 35/35][IPC code unknown for A61K 35/51]
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
02
Inorganic compounds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
06
Organic compounds
08
containing oxygen
12
Carboxylic acids; Salts or anhydrides thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
06
Organic compounds
26
Carbohydrates
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07
Animal cells or tissues
071
Vertebrate cells or tissues, e.g. human cells or tissues
077
Mesenchymal cells, e.g. bone cells, cartilage cells, marrow stromal cells, fat cells or muscle cells
0775
Mesenchymal stem cells; Adipose-tissue derived stem cells
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07
Animal cells or tissues
071
Vertebrate cells or tissues, e.g. human cells or tissues
078
Cells from blood or from the immune system
Applicants:
ロート製薬株式会社 ROHTO PHARMACEUTICAL CO., LTD. [JP/JP]; 大阪府大阪市生野区巽西1丁目8番1号 1-8-1, Tatsumi-nishi, Ikuno-ku, Osaka-shi, Osaka 5448666, JP
Inventors:
武田 里枝 TAKEDA Rie; JP
長岡 くみ子 NAGAOKA Kumiko; JP
堀内 陽子 HORIUCHI Youko; JP
長谷川 輝 HASEGAWA Hikari; JP
玉田 琴絵 TAMADA Kotoe; JP
Agent:
特許業務法人 津国 TSUKUNI & ASSOCIATES; 東京都千代田区麹町5-3-1 麹町ビジネスセンター Kojimachi Business Center, 5-3-1, Kojimachi, Chiyoda-ku, Tokyo 1020083, JP
山村 大介 YAMAMURA Daisuke; JP
森田 慶子 MORITA Yoshiko; JP
Priority Data:
2016-25663228.12.2016JP
Title (EN) CELL PHARMACEUTICAL COMPOSITION, DISEASE TREATMENT KIT, AND CELL SUSPENSION SOLUTION
(FR) COMPOSITION PHARMACEUTIQUE DE CELLULES, KIT POUR TRAITEMENT DE MALADIE, ET SOLUTION POUR SUSPENSION DE CELLULES
(JA) 細胞医薬組成物、疾患治療用キット及び細胞懸濁用溶液
Abstract:
(EN) The present invention addresses the issue of providing a cell pharmaceutical composition capable of maintaining a cell state well and a high survival rate over the long term. This cell pharmaceutical composition contains cells (A) and a cell suspension solution (B) including electrolytes and carbohydrates. The electrolytes in the cell suspension solution (B) include Na+ and Cl and do not substantially include K+. Ideally, the electrolytes in the cell suspension solution (B) would also be substantially only Na+ and Cl or substantially only Na+, Cl, and Lac.
(FR) L’invention a pour objet de fournir une composition pharmaceutique de cellules qui préserve de manière satisfaisante l’état de cellules, et qui permet de maintenir un taux de survie élevé sur une longue durée. Plus précisément, l’invention concerne une composition pharmaceutique de cellules qui comprend des cellules (A), et une solution pour suspension de cellules (B) contenant un électrolyte et un glucide. Ledit électrolyte de la solution pour suspension de cellules (B), contient Na et Cl, mais ne contient pas de manière pratique de K. En outre, de préférence, ledit électrolyte de la solution pour suspension de cellules (B), de manière pratique consiste en Na et Cl uniquement, ou en Na, Cl et uniquement.
(JA) 本発明は、細胞の状態を良好に保ち、生存率を長時間に渡って高く維持することができる細胞医薬組成物を提供することを課題とする。 本発明は、(A)細胞、並びに(B)電解質及び糖質を含む細胞懸濁用溶液を含有し、(B)細胞懸濁用溶液における上記電解質が、Na及びClを含み、Kを実質的に含まない、細胞医薬組成物である。(B)細胞懸濁用溶液における上記電解質はまた、実質的にNa及びClのみ、又は実質的にNa、Cl及びLacのみであることが好ましい。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)