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1. (WO2018123507) CANCER THERAPY UTILIZING COMBINATION OF ORAL TUMOR VACCINE AND IMMUNOSUPPRESSION INHIBITOR

Pub. No.:    WO/2018/123507    International Application No.:    PCT/JP2017/044123
Publication Date: Fri Jul 06 01:59:59 CEST 2018 International Filing Date: Sat Dec 09 00:59:59 CET 2017
IPC: A61K 39/395
A61K 35/745
A61K 39/02
A61K 45/00
A61K 48/00
A61P 13/08
A61P 35/00
A61P 37/04
C07K 14/185
C07K 14/82
C12N 15/09
Applicants: NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY
国立大学法人神戸大学
OSAKA UNIVERSITY
国立大学法人大阪大学
Inventors: SHIRAKAWA, Toshiro
白川 利朗
HASHII, Yoshiko
橋井 佳子
Title: CANCER THERAPY UTILIZING COMBINATION OF ORAL TUMOR VACCINE AND IMMUNOSUPPRESSION INHIBITOR
Abstract:
The present invention addresses the problem of providing a combination therapy which is effective in a cancer immunotherapy. The problem can be solved by providing an anti-tumor agent which contains DNA encoding WT1 protein and DNA encoding a bifidobacterium-origin GNB/LNB substrate-binding membrane protein, and contains a transgenic bifidobacterium that is so designed that WT1 protein can be presented as an antigen on the surface layer of the bifidobacterium, and is combined with an immunosuppression inhibitor upon use. The transgenic bifidobacterium can be used as an oral tumor vaccine.