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1. (WO2018122746) ISOQUINOLINE COMPOUNDS, METHODS FOR THEIR PREPARATION, AND THERAPEUTIC USES THEREOF IN CONDITIONS ASSOCIATED WITH THE ALTERATION OF THE ACTIVITY OF BETA GALACTOSIDASE
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Pub. No.: WO/2018/122746 International Application No.: PCT/IB2017/058438
Publication Date: 05.07.2018 International Filing Date: 27.12.2017
IPC:
C07D 401/14 (2006.01) ,C07D 405/14 (2006.01) ,C07D 217/22 (2006.01) ,C07D 401/12 (2006.01) ,C07D 405/12 (2006.01) ,C07D 417/14 (2006.01) ,A61P 3/00 (2006.01) ,A61P 43/00 (2006.01) ,A61K 31/4725 (2006.01)
Applicants: MINORYX THERAPEUTICS S.L.[ES/ES]; Av. Ernest Lluch 32, TCM3 08302 Mataró Barcelona, ES
Inventors: GARCÍA COLLAZO, Ana Maria; ES
MARTINELL PEDEMONTE, Marc; ES
CUBERO JORDÀ, Elena; ES
BARRIL ALONSO, Xavier; ES
RODRIGUEZ PASCAU, Laura Pilar; ES
Priority Data:
16382660.528.12.2016EP
Title (EN) ISOQUINOLINE COMPOUNDS, METHODS FOR THEIR PREPARATION, AND THERAPEUTIC USES THEREOF IN CONDITIONS ASSOCIATED WITH THE ALTERATION OF THE ACTIVITY OF BETA GALACTOSIDASE
(FR) COMPOSÉS D'ISOQUINOLÉINE, LEURS MÉTHODES DE PRÉPARATION ET LEURS UTILISATIONS THÉRAPEUTIQUES DANS DES MALADIES ASSOCIÉES À L'ALTÉRATION DE L'ACTIVITÉ DE LA BÊTA GALACTOSIDASE
Abstract: front page image
(EN) The application is directed to compounds of formula (I) : (I), and formula (IA): (IA) and their salts and solvates, wherein R1, R2, R3, R4, R5, n, A1, A2, A3, and Y are as set forth in the specification, as well as to a method for their preparation, pharmaceutical compositions comprising the same, and use thereof for the treatment and/or prevention of conditions associated with the alteration of the activity of β-galactosidase, specially galactosidase beta- 1 or GLB 1, including GM 1 gangliosidoses and Morquio syndrome, type B.
(FR) L'application concerne des composés de formule (I) : (I), et de formule (IA) :(IA) et leurs sels et solvates, R1, R2, R3, R4, R5, n, A1, A2, A3, et Y étant comme indiqués dans la spécification, ainsi qu'une méthode pour leur préparation, des compositions pharmaceutiques les comprenant et leur utilisation pour le traitement et/ou la prévention de maladies associés à l'altération de l'activité de la β-galactosidase, particulièrement la galactosidase bêta-1 ou GLB1, y compris des gangliosidoses à GM1 et le syndrome de Morquio de type B.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)