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1. (WO2018122746) ISOQUINOLINE COMPOUNDS, METHODS FOR THEIR PREPARATION, AND THERAPEUTIC USES THEREOF IN CONDITIONS ASSOCIATED WITH THE ALTERATION OF THE ACTIVITY OF BETA GALACTOSIDASE

Pub. No.:    WO/2018/122746    International Application No.:    PCT/IB2017/058438
Publication Date: Fri Jul 06 01:59:59 CEST 2018 International Filing Date: Thu Dec 28 00:59:59 CET 2017
IPC: C07D 401/14
C07D 405/14
C07D 217/22
C07D 401/12
C07D 405/12
C07D 417/14
A61P 3/00
A61P 43/00
A61K 31/4725
Applicants: MINORYX THERAPEUTICS S.L.
Inventors: GARCÍA COLLAZO, Ana Maria
MARTINELL PEDEMONTE, Marc
CUBERO JORDÀ, Elena
BARRIL ALONSO, Xavier
RODRIGUEZ PASCAU, Laura Pilar
Title: ISOQUINOLINE COMPOUNDS, METHODS FOR THEIR PREPARATION, AND THERAPEUTIC USES THEREOF IN CONDITIONS ASSOCIATED WITH THE ALTERATION OF THE ACTIVITY OF BETA GALACTOSIDASE
Abstract:
The application is directed to compounds of formula (I) : (I), and formula (IA): (IA) and their salts and solvates, wherein R1, R2, R3, R4, R5, n, A1, A2, A3, and Y are as set forth in the specification, as well as to a method for their preparation, pharmaceutical compositions comprising the same, and use thereof for the treatment and/or prevention of conditions associated with the alteration of the activity of β-galactosidase, specially galactosidase beta- 1 or GLB 1, including GM 1 gangliosidoses and Morquio syndrome, type B.